GLUCAGON-LIKE PEPTIDE-1(7-36)AMIDE AND GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE SECRETION IN RESPONSE TO NUTRIENT INGESTION IN MAN - ACUTE POSTPRANDIAL AND 24-H SECRETION PATTERNS
GLUCAGON-LIKE PEPTIDE-1(7-36)AMIDE AND GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE SECRETION IN RESPONSE TO NUTRIENT INGESTION IN MAN - ACUTE POSTPRANDIAL AND 24-H SECRETION PATTERNS
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DOI：
10.1677/joe.0.1380159
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发表时间：
1993-07-01
影响因子：
4
通讯作者：
MARKS, V
中科院分区：
文献类型：
--
作者：
ELLIOTT, RM;MORGAN, LM;MARKS, V
比较了不同营养素对正常人胰高血糖素样肽-1（7-36）酰胺（GLP-1（7-36）酰胺）和葡萄糖依赖性胰岛素多肽（GIP）分泌的急性影响。在受试者食用混合饮食的24小时内，测量了这两种激素的循环水平。在第一项研究中，8名受试者吃了3顿等量（375千卡）的碳水化合物、脂肪和蛋白质测试餐。饭后血浆GLP-1（7-36）酰胺均有小幅升高。在碳水化合物负荷后30分钟和脂肪负荷后150分钟达到最大值。摄入碳水化合物和脂肪均可导致GIP分泌显著增加，而蛋白质粉则没有影响。在第二项研究中，8名受试者消耗了75克葡萄糖或相当于煮糙米或大麦的复合碳水化合物。三餐后血浆GIP、胰岛素和葡萄糖水平均有所增加，葡萄糖餐后增幅最大，大麦餐后增幅最小。血浆GLP-1（7-36）酰胺水平仅在葡萄糖餐后升高。在24小时的研究中，血浆GLP-1（7-36）酰胺和GIP浓度在每顿饭后增加，并在白天保持升高，仅在夜间降至禁食水平。碳水化合物或混合膳食后循环GLP-1（7-36）酰胺和GIP水平的增加与它们作为肠促胰岛素的作用一致。在24小时的研究中，白天观察到的更持续的升高与脂质代谢的合成代谢作用一致。
The acute effects of different macronutrients on the secretion of glucagon-like peptide-1(7-36)amide (GLP-1(7-36)amide) and glucose-dependent insulinotropic polypeptide (GIP) were compared in healthy human subjects. Circulating levels of the two hormones were measured over a 24-h period during which subjects consumed a mixed diet. In the first study, eight subjects consumed three equicaloric (375 kcal) test meals of carbohydrate, fat and protein. Small increases in plasma GLP-1(7-36) amide were found after all meals. Levels reached a maximum 30 min after the carbohydrate and 150 min after the fat load. Ingestion of both carbohydrate and fat induced substantial rises in GIP secretion, but the protein meal had no effect. In a second study, eight subjects consumed 75 g glucose or the equivalent portion of complex carbohydrate as boiled brown rice or barley. Plasma GIP, insulin and glucose levels increased after all three meals, the largest increase being observed following glucose and the smallest following the barley meal. Plasma GLP-1(7-36)amide levels rose only following the glucose meal. In the 24-h study, plasma GLP-1(7-36)amide and GIP concentrations were increased following every meal and remained elevated throughout the day, only falling to fasting levels at night. The increases in circulating GLP-1(7-36)amide and GIP levels following carbohydrate or a mixed meal are consistent with their role as incretins. The more sustained rises observed in the daytime during the 24-h study are consistent with an anabolic role in lipid metabolism.