Significance of Haemodynamic and Haemostatic Factors in the Course of Different Manifestations of Cerebral Small Vessel Disease: The SHEF-CSVD Study-Study Rationale and Protocol.
Significance of Haemodynamic and Haemostatic Factors in the Course of Different Manifestations of Cerebral Small Vessel Disease: The SHEF-CSVD Study-Study Rationale and Protocol.
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DOI：
10.1155/2013/424695
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
Stępień A
中科院分区：
文献类型：
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作者：
Staszewski J;Piusińska-Macoch R;Skrobowska E;Brodacki B;Pawlik R;Dutkiewicz T;Piechota W;Rączka A;Tomczykiewicz K;Stępień A
基本原理。本文介绍了SHEF-CSVD研究的基本原理和设计，该研究旨在确定脑血管病（CSVD）的长期临床和放射学病程，并评估该疾病的止血和血流动力学预后因素。设计。这项单中心、前瞻性、非干预性队列研究将连续随访150例不同临床表现的CSVD患者（腔隙性缺血性卒中、血管性痴呆、血管性帕金森病或自发性深部脑出血）和50例年龄和性别匹配的对照组，随访时间为24个月。临床和放射学课程将根据详细的神经学，神经心理学和MRI检查进行评估。将测定血流动力学（脑血管反应性、24小时血压控制）和止血因子（内皮和血小板功能障碍标志物、肱动脉血流介导扩张试验）。讨论。预定的研究将专门研究血流动力学和血流静压预后因素及其在各种临床表现中的病程。这些发现可能有助于制定预防策略和个性化治疗计划，这在疾病的早期阶段至关重要。
Rationale. This paper describes the rationale and design of the SHEF-CSVD Study, which aims to determine the long-term clinical and radiological course of cerebral small vessel disease (CSVD) and to evaluate haemostatic and haemodynamic prognostic factors of the condition. Design. This single-centre, prospective, non-interventional cohort study will follow 150 consecutive patients with different clinical manifestations of CSVD (lacunar ischaemic stroke, vascular dementia, vascular parkinsonism or spontaneous deep, intracerebral haemorrhage) and 50 age- and sex-matched controls over a period of 24 months. The clinical and radiological course will be evaluated basing on a detailed neurological, neuropsychological and MRI examinations. Haemodynamic (cerebral vasoreactivity, 24 h blood pressure control) and haemostatic factors (markers of endothelial and platelet dysfunction, brachial artery flow-mediated dilatation test) will be determined. Discussion. The scheduled study will specifically address the issue of haemodynamic and haemostatic prognostic factors and their course over time in various clinical manifestations of CSVD. The findings may aid the development of prophylactic strategies and individualised treatment plans, which are critical during the early stages of the disease.