Dependence of cardiac filling pressure on cardiac output during rest and dynamic exercise in dogs.
Dependence of cardiac filling pressure on cardiac output during rest and dynamic exercise in dogs.
复制标题
狗休息和动态运动时心脏充盈压对心输出量的依赖性。
DOI：
10.1152/ajpheart.1993.265.1.h316
复制
发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Rowell,LB
中科院分区：
文献类型：
--
作者：
Sheriff,DD;Zhou,XP;Scher,AM;Rowell,LB
静息时，中心静脉压（CVP）福尔斯，心输出量（CO）上升。这可以归因于从中央血管到外周血管的血容量的流量依赖性再分布。相反，尽管CO升高，但动态运动期间CVP升高。因此，运动期间外周循环的变化必须抵消CO在休息期间升高时降低CVP的因素。我们的目标是确定血流的重要性，肌肉泵，并在动态运动过程中心室充盈压的变化反射。在7只手术产生房室（AV）阻滞的犬中，通过休息和运动期间的AV连接起搏（正常心率）建立了CO和CVP之间的正常关系。通过改变心室起搏频率，在休息和踏车运动（0、10或20%等级，4英里/小时）期间改变心输出量，以建立Δ CVP与Δ CO之间的关系曲线。由于肌肉泵的作用，这些曲线在运动时发生位移（较高CO）和向上位移（较高CVP）。在休息和运动期间通过起搏改变CO显示Δ CVP/Δ CO的恒定斜率为-2.7 mmHg.l-1.min-1。在休息时和轻度运动时用六甲铵阻断反射性血管收缩和静脉收缩（以隔离肌肉泵的作用）并没有改变这些斜率或运动引起的曲线位移，尽管在阻断后给定CO时CVP降低了4.3 mmHg。（250字处删节）
At rest, central venous pressure (CVP) falls when cardiac output (CO) rises. This can be attributed to flow-dependent redistribution of blood volume from central to peripheral blood vessels. In contrast, CVP rises during dynamic exercise despite a rise in CO. Therefore peripheral circulatory changes during exercise must counteract the factors that lower CVP when CO rises during rest. Our objectives were to determine the importance of blood flow, the muscle pump, and reflexes on changes in ventricular filling pressure during dynamic exercise. In seven dogs with a surgically produced atrioventricular (AV) block, normal relationships between CO and CVP were established by AV-linked pacing (normal heart rates) during rest and exercise. Cardiac output was altered during rest and treadmill exercise (4 miles/h at 0, 10, or 20% grade) by changing ventricular pacing rate to establish curves relating delta CVP to delta CO. These curves were displaced rightward (higher CO) and upward (higher CVP) by exercise because of the muscle pump. Changing CO by pacing during rest and exercise revealed a constant slope for delta CVP/delta CO of -2.7 mmHg.l-1.min-1. Blockade of reflex vasoconstriction and venoconstriction with hexamethonium at rest and during mild exercise (to isolate effects of the muscle pump) did not alter these slopes or the displacement of the curves by exercise, although CVP was 4.3 mmHg lower at a given CO after blockade.(ABSTRACT TRUNCATED AT 250 WORDS)