Collagen biosynthesis in normal and hypertrophic scars and keloid as a function of the duration of the scar
Collagen biosynthesis in normal and hypertrophic scars and keloid as a function of the duration of the scar
复制标题
正常和肥厚性疤痕以及疤痕疙瘩中的胶原蛋白生物合成与疤痕持续时间的关系
DOI：
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发表时间：
1975
影响因子：
9.6
通讯作者：
D. Jackson
中科院分区：
文献类型：
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作者：
R. D. Peter Craig;J. David Schofield;D. Jackson
正常瘢痕、增生性瘢痕和瘢痕疙瘩中胶原的生物合成速率和组织中胶原的浓度被确定为病变持续时间的函数。正常瘢痕中的胶原蛋白合成速率在初始创伤后6个月至20年之间大致恒定，但在增生性瘢痕和瘢痕疙瘩中，该速率最初约为正常瘢痕中的两倍，并且在创伤后2 - 3年，其下降至与正常瘢痕中大致相同的水平。在正常瘢痕中，胶原蛋白的组织浓度似乎相对恒定，但在两种类型的异常瘢痕中，其最初略低于正常瘢痕，然后在约2 - 3年后升至高于正常瘢痕的值。由于两种类型的异常瘢痕在胶原蛋白生物合成速率方面相对于创伤后经过的时间以及在胶原蛋白的组织浓度方面获得了相似的结果，这可能表明两种异常瘢痕类型的发病机制中的事件是相似的。结果还提出了两种类型的异常瘢痕形成可能发生在两个阶段的可能性：以胶原蛋白生物合成的异常高速率为特征的初始阶段，以及以胶原蛋白生物合成的基本正常速率为特征的后期阶段。
The rates of collagen biosynthesis and the tissue concentrations of collagen in normal scar, hypertrophic scar and keloid were determined as a function of the duration of the lesions. The rate of collagen synthesis in normal scar was approximately constant between 6 months and 20 years after the initial wounding, but in both hypertrophic scar and keloid the rate was initially approximately twice that in normal scar, and 2‐3 years after wounding it fell to approximately the same level as in normal scar. The tissue concentration of collagen appeared to be relatively constant in normal scar with respect to the time elapsed after wounding, but in both types of abnormal scar it was initially somewhat lower than normal scar and then rose to values higher than in normal scar after about 2‐3 years. Since similar results were obtained for both types of abnormal scar in terms of the rates of collagen biosynthesis with respect to the time elapsed after wounding and also in terms of the tissue concentrations of collagen, this may indicate that the events in the pathogenesis of both abnormal scar types are similar. The results also raise the possibility that the formation of both types of abnormal scar may occur in two phases: an initial phase characterized by abnormally high rates of collagen biosynthesis, and a later phase characterized by essentially normal rates of collagen biosynthesis.