Hospital-based study of risk factors associated with development of myopic macular neovascularization in highly myopic eyes
Hospital-based study of risk factors associated with development of myopic macular neovascularization in highly myopic eyes
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高度近视眼近视黄斑新生血管形成相关危险因素的医院研究
DOI：
10.1159/000527183
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发表时间：
2023
影响因子：
2.1
通讯作者：
Ohno-Matsui Kyoko
中科院分区：
文献类型：
--
作者：
Du Ran;Xie Shiqi;Lu Hongshuang;Chen Changyu;Xiong Jianping;Uramoto Kengo;Takahashi Hiroyuki;Onishi Yuka;Kamoi Koju;Nakao Noriko;Fang Yuxin;Ohno-Matsui Kyoko
近视性黄斑新生血管（MNV）是病理性近视眼中心视力下降的最常见原因，长期可发展为黄斑萎缩。本研究的目的是确定与MNVs.MethodsThere的发展相关的风险因素，有17,198随访记录从5,409眼的2,784高度近视患者进行了审查。对病历中的一般信息和眼科信息进行分析。分析近视眼MNV发生的相关因素及预测MNV发生的意义（比值比[OR]= 0.727，p< 0.001），具有较长的轴向长度（OR= 0.948，p< 0.001），基线最佳矫正视力较差（BCVA，OR= 2.098，p< 0.001），患有重度近视黄斑病变（总体：p< 0.001），对侧眼既往近视MNV（OR= 4.105，p< 0.001），存在斑片状萎缩（总体p< 0.001），漆裂纹（OR= 1.718，p< 0.001），既往中心凹视网膜脱离（RD，OR= 3.269，p< 0.001），既往黄斑裂孔（MH，OR= 0.641，p< 0.001）、先前黄斑视网膜劈裂（OR= 1.533，p< 0.001）和先前黄斑水肿（OR= 1.508，p< 0.001）与近视MNV的发生显著相关。患有MNV和斑片状萎缩的眼睛需要对近视患者进行密集的随访检查，因为对侧眼在3年内发生近视MNV的风险> 70%，在5年内发生近视MNV的风险接近80%。和先前的中心凹视网膜脱离以确定近视MNV的发作。
IntroductionMyopic macular neovascularization (MNV) is the most common cause of a reduction of central vision in eyes with pathologic myopia, and it can progress to macular atrophy in the long term. The aim of this study was to determine the risk factors associated with the development of MNVs.MethodsThere were 17,198 follow-up records from 5,409 eyes of 2,784 highly myopic patients that were reviewed. The general information and ophthalmic information in the records were studied. The significance of the correlations of factors associated with the development and predicting the development of myopic MNV were determined.ResultsBeing a woman (odds ratio [OR]= 0.727, p< 0.001), having a longer axial length (OR= 0.948, p< 0.001), having a poorer baseline best-correct visual acuity (BCVA, OR= 2.098, p< 0.001), having severe myopic maculopathy (overall: p< 0.001), prior myopic MNV in the fellow eye (OR= 4.105, p< 0.001), presence of patchy atrophy (overall p< 0.001), lacquer cracks (OR= 1.718, p< 0.001), prior foveal retinal detachment (RD, OR= 3.269, p< 0.001), prior macular hole (MH, OR= 0.641, p< 0.001), prior macular retinoschisis (OR= 1.533, p< 0.001), and prior macular edema (OR= 1.508, p< 0.001) were significantly correlated with the development of myopic MNV. Eyes with MNV and patchy atrophy would require an intensive follow-up examination for myopic patients as the fellow eye would have a risk of> 70% for the development of myopic MNV in 3 years and nearly 80% in 5 years.ConclusionsClinicians need to pay special attention to eyes with severe grades of myopic maculopathy, prior myopic MNV in the fellow eye, presence of patchy atrophy, and prior foveal retinal detachment to determine the onset of myopic MNV.