Diagnosis of alcohol misuse and alcoholic liver disease among patients in the medical emergency admission service of a large urban hospital in Sub-Saharan Africa; a cross sectional study.
Diagnosis of alcohol misuse and alcoholic liver disease among patients in the medical emergency admission service of a large urban hospital in Sub-Saharan Africa; a cross sectional study.
复制标题
DOI：
10.11604/pamj.2013.15.23.2040
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Lee WM
中科院分区：
文献类型：
--
作者：
Opio CK;Seremba E;Ocama P;Lalitha R;Kagimu M;Lee WM
乌干达是全球十大酒精消费国之一，尽管几乎没有与酒精相关的肝病数据。我们描述了乌干达一家大型城市医院急诊服务中成年人的酒精使用、酒精滥用和酒精性肝病。所有同意的成年人都通过询问和酒精滥用的“削减，烦恼，内疚和大开眼界-笼”问卷进行了前瞻性评估。使用天冬氨酸转氨酶和丙氨酸转氨酶水平评估酒精相关的肝细胞肝损伤。CAGE评分≥2和De Ritis比率≥2的组合定义为酒精性肝病（ALD）。对所有患者进行了人类免疫缺陷病毒（HIV）、病毒性肝炎B和C血清学评价。描述性和推理性的统计数据，以回答我们的研究问题。380名受试者同意并参与了研究。其中，46.8%承认使用酒精，而21%和10%分别符合酒精滥用和酒精性肝病的研究定义。在单变量和多变量分析后，酒精滥用和酒精性肝病与男性性别、原籍地区、终生性伴侣数量和血清白蛋白低于3.5 mg/dl显著相关（p值≤ 0.05）。酒精滥用和酒精性肝病是经常在这个医疗急救单位。我们的研究表明，酒精滥用或酒精性肝病与男性性别，原籍地区，性伴侣数量和血清白蛋白低于3.5mg/dl之间存在联系。
Uganda is among the top ten consumers of alcohol worldwide though there is little data on alcohol related liver disease. We describe alcohol use, alcohol misuse, and alcoholic liver disease among adults at the emergency admission service of a large urban hospital in Uganda. All adults who consented were prospectively evaluated for alcohol use by inquiry and alcohol misuse by the “Cutting down, Annoyance, Guilt and Eye-opener- CAGE” questionnaire. Alcohol related hepatocellular liver injury was assessed using aspartate aminotransferase, and alanine aminotransferase levels. A combination of CAGE score ≥2 and De Ritis ratio ≥2 defined alcoholic liver disease (ALD). Human Immunodeficiency Virus (HIV), and viral hepatitis B and C serologies were evaluated in all the patients. Descriptive and inferential statistics were generated to answer our research questions. Three hundred and eighty individuals consented and participated in the study. Among these, 46.8% acknowledged use of alcohol while 21% and 10% met the study definition of alcoholic misuse and alcoholic liver disease respectively. Both alcohol misuse and alcoholic liver disease was significantly associated (p-value ≤ 0.05) with male gender, region of origin, number of life time sexual partners and serum albumin below 3.5 mg/dl after univariate and multivariate analysis. Alcohol misuse and alcoholic liver disease is frequent in this medical emergency unit. Our study suggests a link between alcohol misuse or alcoholic liver disease and male gender, region of origin, number of sexual partners, and serum albumin below 3.5mg/dl.