The interaction of the serotonergic and dopaminergic systems on prolactin secretion in the rat. The mechanism of action of the "specific" serotonin receptor antagonist, methysergide.
The interaction of the serotonergic and dopaminergic systems on prolactin secretion in the rat. The mechanism of action of the "specific" serotonin receptor antagonist, methysergide.
复制标题
血清素能和多巴胺能系统对大鼠催乳素分泌的相互作用。
DOI：
10.1210/endo-103-1-287
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发表时间：
1978
期刊：
影响因子：
4.8
通讯作者：
ROBERT M. Macleod
中科院分区：
文献类型：
--
作者：
S. W. Lamberts;ROBERT M. Macleod
本研究分析了孕酮能系统分泌催乳素的机制及麦角新碱的抑制作用。给大鼠注射5-羟色氨酸（5-HTP）可使血清PRL浓度显著升高。在体外，这些大鼠的脑垂体合成和分泌的PRL量与未治疗的大鼠相似。与多巴胺能系统的相互作用进行了研究，通过测试这些垂体在体外多巴胺的敏感性。在体外实验中，在对照组和注射5-HT的大鼠中观察到500 nM多巴胺对PRL分泌的可比抑制作用。当垂体在多巴胺的存在下孵育时，在5-HT处理的大鼠的腺体中观察到PRL合成的显着增加。5-HTP和5-羟色胺在体外对PRL分泌均无直接影响。这表明，5-羟色胺前体通过下丘脑而不是在脑垂体对PRL分泌产生刺激作用。阿德米尼...
In this study, the mechanisms governing the secretion of PRL by the serotonergic system and the inhibitory effects of methysergide were analyzed. The injection of 5-hydroxytryptophan (5-HTP) into rats greatly increased the serum PRL concentration. In vitro, the pituitary gland from these rats synthesized and secreted amounts of PRL similar to those produced by nontreated rats. Interaction with the dopaminergic system was investigated by testing the sensitivity of these pituitary glands in vitro to dopamine. In vitro, a comparable inhibitory effect of 500 nM dopamine on PRL secretion was observed in both control and 5-HTP-injected rats. A significant increase in PRL synthesis was observed in glands from 5-HTP-treated rats when the pituitaries were incubated in the presence of dopamine. Neither 5-HTP nor serotonin had a direct in vitro effect on PRL secretion. It is suggested that serotonin precursors exert their stimulatory effect on PRL secretion via the hypothalamus and not at the pituitary gland. Admini...