Comparative mapping of Na+-phosphate cotransporter genes, NPT1 and NPT2, in human and rabbit.
Comparative mapping of Na+-phosphate cotransporter genes, NPT1 and NPT2, in human and rabbit.
复制标题
人和兔中磷酸钠协同转运蛋白基因 NPT1 和 NPT2 的比较图谱。
DOI：
10.1159/000134449
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
H. Tenenhouse
中科院分区：
文献类型：
--
作者：
C. Kos;F. Tihy;H. Murer;N. Lemieux;H. Tenenhouse
通过荧光原位杂交确定了兔（Oryctolagus cuniculus）Na+-磷酸盐协同转运蛋白基因NPT1和NPT2的染色体位置。我们的结果将 NPT1 定位于兔染色体 12p11，将 NPT2 定位于兔染色体 3p11。人类中相应的基因分别映射到染色体带 6p22 和 5q35。这些分配与先前报道的兔 12 号染色体和人类 6 号染色体之间的同源性一致，并为建立兔 3 号染色体和人类 5 号染色体之间保守的同线性群提供了基础。
The chromosome locations of the rabbit (Oryctolagus cuniculus) Na+-phosphate cotransporter genes NPT1 and NPT2 were determined by fluorescence in situ hybridization. Our results localize NPT1 to rabbit chromosome 12p11 and NPT2 to rabbit chromosome 3p11. The corresponding genes in the human map to chromosome bands 6p22 and 5q35, respectively. These assignments agree with the previously reported homology between rabbit chromosome 12 and human chromosome 6 and provide the basis for the establishment of a conserved syntenic group between rabbit chromosome 3 and human chromosome 5.