Molecular epidemiology of acute hemorrhagic conjunctivitis caused by coxsackie A type 24 variant in China, 2004-2014.
Molecular epidemiology of acute hemorrhagic conjunctivitis caused by coxsackie A type 24 variant in China, 2004-2014.
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2004-2014年中国柯萨奇A型24变种引起的急性出血性结膜炎分子流行病学分析
DOI：
10.1038/srep45202
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发表时间：
2017-03-23
影响因子：
4.6
通讯作者：
Liu S
中科院分区：
文献类型：
--
作者：
Zhang L;Zhao N;Huang X;Jin X;Geng X;Chan TC;Liu S
为了解控制干预措施，对2004 - 2014年急性出血性结膜炎（AHC）的分子流行病学进行了调查，共纳入613，485例AHC病例（年化病例55，771例），其中2例死亡。我们的研究结果显示，AHC在所有省份均有报告，主要在华南和华东地区。发病率最高的年份分别为2007年（5.65/10万）和2010年（21.78/10万）。一个明确的季节性模式，确定了从8月到10月的高峰。所有年龄组均发生AHC病例;然而，5至14岁是主要年龄组[23.06%，133，510/578，909]。中位年龄24岁（1个月~97岁）。从发病到确诊的中位时间为1.5天，<15岁、15~60岁和>60岁患者之间无差异[p = 0.0653]。对100个非结构蛋白（3C）和84个结构蛋白（VP 1）的系统发育分析表明，AHC暴发是由柯萨奇病毒A24变异株引起的。基因型G4-c5 a、G4-c5 b和G4-c3在时间和地理上都有重叠。综上所述，尽管自2010年高峰期以来，AHC病例数量总体上稳步下降，但在中国南部和东部，针对15岁以下学龄儿童的AHC仍然是一个严重的公共卫生问题。
To understand control interventions, the molecular epidemiology of acute hemorrhagic conjunctivitis (AHC) was investigated from 2004 to 2014.A total of 613,485 AHC cases (annualized cases 55,771) with two deaths were included. Our findings showed that AHC was reported in all provinces, predominantly in Southern and Eastern China. The incidence rates were highest in 2007 (5.65/100,000) and 2010 (21.78/100,000) respectively. A clear seasonal pattern was identified with a peak from August to October. AHC cases occurred in all age groups; however, five to 14 years was the predominant group [23.06%, 133, 510/578,909]. The median age was 24 years (one month~97 years). The median duration from onset to diagnosis was 1.5 days, and there was no difference between the <15, 15~60 and >60-year-old patients [p = 0.0653]. The phylogenetic analysis of 100 nonstructural proteins (3C) and 84 structural proteins (VP1) revealed that AHC outbreaks were caused by Coxsackievirus A24 variant. Genotypes G4-c5a, G4-c5b, and G4-c3 co-circulated with both temporal and geographical overlaps. In conclusion, despite the overall steady decline in the number of AHC cases since the peak in 2010, it still remains a serious public health problem in Southern and Eastern China that targets on the school aged children under 15 years old.