Airway responsiveness to cold air and hyperpnea in normal subjects and in those with hay fever and asthma.
Airway responsiveness to cold air and hyperpnea in normal subjects and in those with hay fever and asthma.
复制标题
正常受试者以及花粉热和哮喘患者的气道对冷空气和呼吸过度的反应。
DOI：
10.1164/arrd.1980.121.4.621
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
J. Jaeger
中科院分区：
文献类型：
--
作者：
E. Deal;E. Mcfadden;R. Ingram;F. J. Breslin;J. Jaeger
在20名正常对照者、16名花粉热患者和44名无症状哮喘患者中，测量了呼吸过度和吸入冷空气进行支气管激发前后肺力学的多个方面。这些挑战对正常受试者的肺功能没有影响。然而，在花粉热组中，激发后机制改变了一个小的，但显着的量，例如，一秒钟用力呼气量（FEV 1）的平均下降为-5.1 +/- 1.7%（SEM）。哮喘患者的反应更明显（FEV 1平均下降-32.7 +/-2.6%）。正常受试者和花粉热患者的反应之间有相当大的重叠，但哮喘患者和正常受试者之间完全没有重叠。花粉热的反应与哮喘反应重叠的唯一受试者是那些偶尔有喘息发作史的人。这种反应模式表明，使用呼吸过度和冰点以下的空气是检测空气反应性增加的一种非常敏感且高度特异性的方法。
Multiple aspects of pulmonary mechanics were measured before and after bronchial challenges consisting of hyperpnea with cold air inhalation in 20 normal control subjects, 16 subjects with hay fever, and 44 asymptomatic asthmatics. These challenges had no effect on the lung function of the normal subjects. In the hay fever group, however, postchallenge mechanics changed a small, but significant, amount, e.g., mean decrease in forced expiratory volume in one second (FEV1) was -5.1 +/- 1.7% (SEM). The asthmatics had a much more marked response (mean fall in FEV1, -32.7 +/- 2.6%). There was considerable overlap between the responses of the normal subjects and those with hay fever, but no overlap at all between asthmatic and normal subjects. The only subjects with hay fever whose responses overlapped the asthmatic response were those who had histories of occasional episodes of wheezing. This pattern of response suggests that the use of hyperpnea and subfreezing air is a very sensitive and highly specific means of detecting increased air reactivity.