Tumor Necrosis Factor-α Antagonists Improve Aortic Stiffness in Patients With Inflammatory Arthropathies A Controlled Study
Tumor Necrosis Factor-α Antagonists Improve Aortic Stiffness in Patients With Inflammatory Arthropathies A Controlled Study
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DOI：
10.1161/hypertensionaha.109.143982
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发表时间：
2010-02-01
期刊：
影响因子：
8.3
通讯作者：
Atar, Dan
中科院分区：
文献类型：
--
作者：
Angel, Kristin;Provan, Sella Aarrestad;Atar, Dan
类风湿性关节炎和其他炎性关节病（如强直性脊柱炎和银屑病关节炎）的慢性炎症状态促成与这些病症相关的加速动脉粥样硬化。本研究评价了肿瘤坏死因子（TNF）-α拮抗剂治疗对炎性关节病患者动脉僵硬度的影响。共纳入了60例患有类风湿性关节炎、强直性脊柱炎或银屑病关节炎且有抗TNF-α治疗临床指征的患者。35例患者开始抗TNF-α治疗，并与25例非治疗组进行比较。在基线和3个月后评估主动脉僵硬度（主动脉脉搏波速度）、增强指数和疾病活动度。治疗组的主动脉脉搏波速度（平均值+/- SD）降低，但对照组未降低（分别为-0.50 +/- 0.78 m/s vs 0.05 +/- 0.54 m/s; P=0.002）。同时，治疗组C-反应蛋白和疾病活动性评分降低（-9.3 +/-20.2 mg/L [P
The chronic inflammatory state of rheumatoid arthritis and other inflammatory arthropathies, such as ankylosing spondylitis and psoriatic arthritis, contributes to the accelerated atherosclerosis associated with these conditions. This study evaluates the effect of treatment with tumor necrosis factor (TNF)-alpha antagonists on arterial stiffness in patients with inflammatory arthropathies. A total of 60 patients with rheumatoid arthritis, ankylosing spondylitis, or psoriatic arthritis and clinical indication for anti-TNF-alpha therapy were included. Thirty-five patients started with anti-TNF-alpha therapy and were compared with a nontreatment group of 25 patients. Aortic stiffness (aortic pulse wave velocity), augmentation index, and disease activity were assessed at baseline and after 3 months. Aortic pulse wave velocity (mean +/- SD) was reduced in the treatment group but not in the control group (-0.50 +/- 0.78 m/s versus 0.05 +/- 0.54 m/s, respectively; P=0.002). Concomitantly, C-reactive protein and the disease activity score were reduced in the treatment group (-9.3 +/- 20.2 mg/L [P