Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor
Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor
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DOI：
10.1126/science.280.5369.1618
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发表时间：
1998-06-05
期刊：
影响因子：
56.9
通讯作者：
Spear, PG
中科院分区：
文献类型：
--
作者：
Geraghty, RJ;Krummenacher, C;Spear, PG
免疫球蛋白超家族的人类成员被证明可以介导多种α疱疹病毒的进入，包括单纯疱疹病毒（HSV）1和2、猪伪狂犬病病毒（PRV）和牛疱疹病毒1（BHV-1）。这种膜糖蛋白是脊髓灰质炎病毒受体相关蛋白 1 (Prr1)，此处称为 HveC，HSV-1 与分泌形式的 HveC 一起孵育可抑制多种细胞系的后续感染，表明 HveC 直接与病毒相互作用。脊髓灰质炎病毒受体 (Pvr) 本身介导 PRV 和 BHV-1 的进入，但不介导测试的 HSV 毒株的进入。 HveC 在人类上皮细胞和神经元来源的细胞中表达；它是辅助受体的主要候选者，使 HSV-1 和 HSV-2 能够感染粘膜表面的上皮细胞并扩散到神经系统细胞。
A human member of the immunoglobulin superfamily was shown to mediate entry of several alphaherpesviruses, including herpes simplex viruses (HSV) 1 and 2, porcine pseudorabies virus (PRV), and bovine Herpesvirus 1 (BHV-1). This membrane glycoprotein is poliovirus receptor-related protein 1 (Prr1), designated here as HveC, Incubation of HSV-1 with a secreted form of HveC inhibited subsequent infection of a variety of cell lines, suggesting that HveC interacts directly with the virus. Poliovirus receptor (Pvr) itself mediated entry of PRV and BHV-1 but not of the HSV strains tested. HveC was expressed in human cells of epithelial and neuronal origin; it is the prime candidate for the coreceptor that allows both HSV-1 and HSV-2 to infect epithelial cells on mucosal surfaces and spread to cells of the nervous system.