Oxygen extraction fraction measurement using quantitative susceptibility mapping: Comparison with positron emission tomography
Oxygen extraction fraction measurement using quantitative susceptibility mapping: Comparison with positron emission tomography
复制标题
DOI：
10.1177/0271678x15606713
复制
发表时间：
2016-08-01
影响因子：
6.3
通讯作者：
Sasaki, Makoto
中科院分区：
文献类型：
--
作者：
Kudo, Kohsuke;Liu, Tian;Sasaki, Makoto
本研究的目的是建立氧提取分数（OEF）测量使用定量磁共振成像（MRI）的磁化率映射（QSM），并比较QSM-OEF数据与金标准O-15正电子发射断层扫描（PET）。26例单侧颈内动脉或大脑中动脉慢性狭窄或闭塞患者和15例正常人。使用3.0特斯拉扫描仪进行MRI扫描，三维扰相梯度回忆序列。使用形态学启用偶极子反演方法创建QSM图像，并使用脱氧血红蛋白诱导的静脉敏感性提取从QSM图像生成OEF图。QSM-OEF与PET-OEF与对侧半球的相对OEF比值呈显著相关（r = 0.62，p < 0.001）。在PET-OEF增加的患者中，局部（切片内）相关性也显著（r = 0.52，p < 0.001）。与PET相比，QSM中OEF增加的敏感性和特异性分别为0.63（5/8）和0.89（16/18）。总之，QSM-OEF和PET-OEF在识别单侧慢性狭窄闭塞性疾病患者受累半球OEF升高方面具有良好的相关性。
The purposes of this study are to establish oxygen extraction fraction (OEF) measurements using quantitative susceptibility mapping (QSM) of magnetic resonance imaging (MRI), and to compare QSM-OEF data with the gold standard O-15 positron emission tomography (PET). Twenty-six patients with chronic unilateral internal carotid artery or middle cerebral artery stenosis or occlusion, and 15 normal subjects were included. MRI scans were conducted using a 3.0 Tesla scanner with a three-dimensional spoiled gradient recalled sequence. QSM images were created using the morphology-enabled dipole inversion method, and OEF maps were generated from QSM images using extraction of venous susceptibility induced by deoxygenated hemoglobin. Significant correlation of relative OEF ratio to contra-lateral hemisphere between QSM-OEF and PET-OEF was observed (r = 0.62, p < 0.001). The local (intra-section) correlation was also significant (r = 0.52, p < 0.001) in patients with increased PET-OEF. The sensitivity and specificity of OEF increase in QSM was 0.63 (5/8) and 0.89 (16/18), respectively, in comparison with PET. In conclusion, good correlation was achieved between QSM-OEF and PET-OEF in the identification of elevated OEF in affected hemispheres of patients with unilateral chronic steno-occlusive disease.