Lineage-specific requirement for signal transducer and activator of transcription (Stat)4 in interferon gamma production from CD4(+) versus CD8(+) T cells.
Lineage-specific requirement for signal transducer and activator of transcription (Stat)4 in interferon gamma production from CD4(+) versus CD8(+) T cells.
复制标题
对CD4（+）与CD8（+）T细胞的干扰素γ产生中转录的信号换能器和转录激活因子（Stat）4的谱系特异性需求。
DOI：
10.1084/jem.189.8.1355
复制
发表时间：
1999-04-19
影响因子：
15.3
通讯作者：
Murphy, K M
中科院分区：
文献类型：
--
作者：
Carter, L L;Murphy, K M
CD4+ 和 CD8+ T 细胞在其主要效应功能方面表现出重要差异。 CD8+ T 细胞通过细胞溶解活性提供针对病原体的保护，而 CD4+ T 细胞通过产生细胞因子发挥重要的调节活性。然而，这两个谱系都可以产生干扰素 (IFN)-γ，这有助于保护性免疫。在这里，我们表明 CD4+ 和 CD8+ T 细胞对 IFN-γ 产生的调节不同。两个谱系都需要信号转导子和转录激活剂 (Stat)4 激活白介素 (IL)-12/IL-18 信号传导诱导的 IFN-γ，但只有 CD4+ T 细胞需要 Stat4 通过 TCR 途径诱导 IFN-γ。响应抗原，CD8+ T 细胞可以独立于 IL-12 产生 IFN-γ，而 CD4+ T 细胞需要 IL-12 和 Stat4 激活。因此，基于 CD4+ 和 CD8+ T 细胞之间 TCR 信号传导的差异，抗原诱导的 IFN-γ 产生中对 Stat4 激活存在谱系特异性要求。
CD4+ and CD8+ T cells exhibit important differences in their major effector functions. CD8+ T cells provide protection against pathogens through cytolytic activity, whereas CD4+ T cells exert important regulatory activity through production of cytokines. However, both lineages can produce interferon (IFN)-γ, which can contribute to protective immunity. Here we show that CD4+ and CD8+ T cells differ in their regulation of IFN-γ production. Both lineages require signal transducer and activator of transcription (Stat)4 activation for IFN-γ induced by interleukin (IL)-12/IL-18 signaling, but only CD4+ T cells require Stat4 for IFN-γ induction via the TCR pathway. In response to antigen, CD8+ T cells can produce IFN-γ independently of IL-12, whereas CD4+ T cells require IL-12 and Stat4 activation. Thus, there is a lineage-specific requirement for Stat4 activation in antigen-induced IFN-γ production based on differences in TCR signaling between CD4+ and CD8+ T cells.