ETHNIC DISPARITY IN HEMOGLOBIN A1c LEVELS AMONG NORMOGLYCEMIC OFFSPRING OF PARENTS WITH TYPE 2 DIABETES MELLITUS
ETHNIC DISPARITY IN HEMOGLOBIN A1c LEVELS AMONG NORMOGLYCEMIC OFFSPRING OF PARENTS WITH TYPE 2 DIABETES MELLITUS
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DOI：
10.4158/ep11245.or
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发表时间：
2012-05-01
影响因子：
4.2
通讯作者：
Dagogo-Jack, Samuel
中科院分区：
文献类型：
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作者：
Chapp-Jumbo, Emmanuel;Edeoga, Chimaroke;Dagogo-Jack, Samuel
目的：为了探讨血红蛋白A（1c）水平的种族/民族差异之间的非糖尿病患者相似的父母2型糖尿病mellitus.Methods的历史：我们研究了一个社区为基础的样本的成年子女的父母与2型糖尿病。测量包括人体测量，血液学评估，系列空腹血糖，口服葡萄糖耐量试验，血浆胰岛素，血红蛋白A（1C），胰岛素敏感性，β细胞功能，使用稳态模型assessment.Results：该研究包括302名参与者（135白色，167黑色）。与白色受试者相比，黑人受试者的空腹血糖水平较低（91.9 +/- 0.51 mg/dL vs 93.6 +/- 0.50 mg/dL，P = 0.015），口服葡萄糖耐量试验期间血糖曲线下面积较低（P = 0.015）。
Objective: To investigate the racial/ethnic disparities in hemoglobin A(1c) levels among nondiabetic persons with similar parental history of type 2 diabetes mellitus.Methods: We studied a community-based sample of adult offspring of parents with type 2 diabetes mellitus. Measurements included anthropometry, hematology assessments, serial fasting plasma glucose, oral glucose tolerance testing, plasma insulin, hemoglobin A(1c), insulin sensitivity, and beta-cell function, using a homeostasis model assessment.Results: The study included 302 participants (135 white, 167 black). Compared with white participants, black participants had lower fasting plasma glucose levels (91.9 +/- 0.51 mg/dL vs 93.6 +/- 0.50 mg/dL, P = .015), lower area under the curve of plasma glucose during oral glucose tolerance testing (P =