HDL-cholesterol and physical performance:: results from the ageing and longevity study in the sirente geographic area (ilSIRENTE Study)
HDL-cholesterol and physical performance:: results from the ageing and longevity study in the sirente geographic area (ilSIRENTE Study)
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DOI：
10.1093/ageing/afm105
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发表时间：
2007-09-01
期刊：
影响因子：
6.7
通讯作者：
Onder, Graziano
中科院分区：
文献类型：
--
作者：
Landi, Francesco;Russo, Andrea;Onder, Graziano
背景高密度脂蛋白（HDL）胆固醇被认为是高龄老年人虚弱和预后不良的可靠标志。我们评估了 80 岁或以上老年人的 HDL-胆固醇与身体表现、肌肉力量和功能状态测量的关系。方法数据来自 Sirente 地理区域衰老和长寿研究的基线评估（ilSIRENTE 研究）（n = 364）。使用身体表现电池评分[短身体表现电池（SPPB）]评估身体表现，该分数基于三项测试：4米步行速度、平衡性和椅立测试。肌肉力量通过握力来测量。进行协方差分析以评估不同HDL-胆固醇水平与身体机能的关系。在未经调整的分析中，随着HDL-胆固醇三分位数的增加，身体机能（通过4米步行速度、SPPB评分、日常生活量表的基本和工具活动评分来测量）显着改善，但握力却没有显着改善。在对潜在的混杂因素（包括年龄、性别、独居、酗酒、体力活动、充血性心力衰竭、糖尿病、脑血管疾病、骨关节炎、白蛋白、尿素、C反应蛋白和低密度脂蛋白胆固醇）进行调整后，HDL-胆固醇三分位数与4米步行速度和SPPB评分的关联仍然一致。结论本研究表明，在社区中生活的高龄受试者中，HDL-胆固醇水平较高与更好的功能性能相关。
Background high-density lipoprotein (HDL) cholesterol has been hypothesised to be a reliable marker of frailty and poor prognosis among the oldest elderly. We evaluate the relationship of HDL-cholesterol with measures of physical performance, muscle strength, and functional status in older persons aged 80years or older.Methods data are from baseline evaluation of the ageing and longevity study in the Sirente geographic area (ilSIRENTE study) (n = 364). Physical performance was assessed using the physical performance battery score [short physical performance battery (SPPB)], which is based on three-timed tests: 4-m walking-speed, balance, and chair-stand tests. Muscle strength was measured by hand-grip strength. Analyses of covariance were performed to evaluate the relationship of different HDL-cholesterol levels with physical function.Results in the unadjusted analyses, physical function (as measured by the 4-m walking-speed, theSPPB score, the basic and instrumental activities of daily living scales scores), but not hand-grip strength, improved significantly as HDL-cholesterol tertiles increased. After adjustment for potential confounders, which included age, gender, living alone, alcohol abuse, physical activity, congestive heart failure, diabetes, cerebrovascular diseases, osteoarthritis, albumin, urea, C-reactive protein and LDL cholesterol, the association of HDL-cholesterol tertiles with the 4-m walking-speed and the SPPB score was still consistent.Conclusion the present study suggests that among very old subjects living in the community the higher levels of HDL-cholesterol are associated with better functional performance.