Association of MC4R gene polymorphisms with growth and body composition traits in chicken
Association of MC4R gene polymorphisms with growth and body composition traits in chicken
复制标题
MC4R 基因多态性与鸡生长和身体成分性状的关联
DOI：
10.5713/ajas.2006.763
复制
发表时间：
2006-06-01
期刊：
影响因子：
--
通讯作者：
Li, H
中科院分区：
文献类型：
--
作者：
Li, CY;Li, H
对小鼠的遗传学和药理学研究表明，黑素皮质素4受体(MC4R)在控制食物摄入量、能量平衡和体重方面具有互补作用。本研究旨在探讨MC4R基因多态性与腹脂肉鸡品系生长和体成分性状的关系。在鸡MC4R基因CDS区发现一个SNP(G54C)。最小二乘方和方差分析表明，G54C SNP与7周龄体重、CW和SL显著相关，且不同基因型间差异显著(p<；0.05)。蛋白质二级结构预测和三级结构预测结果表明，突变蛋白在第13位氨基酸上出现一条螺旋，在第14位和第15位氨基酸上出现两条链。可能引起家禽MC4R基因活性或功能的改变。(亚洲--澳大利亚。J·阿尼姆SCI。2006年。第19卷，第6期：763-768)
Genetic and pharmacological studies in mice have demonstrated a complementary role for the melanocortin 4 receptor (MC4R) in the control of food intake, energy balance and body weight. This study was designed to investigate the associations of a MC4R gene polymorphism on chicken growth and body composition traits in broiler lines divergently selected for abdominal fat. A SNP (G54C) was found in CDS region of chicken MC4R gene. The analysis of the least squares and variance revealed a significant association between the G54C SNP and BW, CW and SL at 7 wk of age, and there were significant differences in different genotypes (p<0.05). The results from protein secondary structure prediction and tertiary structure prediction showed that it appeared a helix in 13 th amino acid and two strands at 14 th and15 th amino acid in mutant protein, respectively. It maybe induce the change of the activity or function of MC4R gene in poultry. (Asian-Aust. J. Anim. Sci. 2006. Vol 19, No. 6 : 763-768)