SnapShot: chromatin remodeling complexes.
SnapShot: chromatin remodeling complexes.
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DOI：
10.1016/j.cell.2007.04.018
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发表时间：
2007-05-04
期刊：
影响因子：
64.5
通讯作者：
Shen, Xuetong
中科院分区：
文献类型：
--
作者：
Bao, Yunhe;Shen, Xuetong
SWR 1调节转录，也参与组蛋白H2 AZ的沉积，染色体稳定性和细胞周期检查点适应。在体外，它可以以ATP依赖性方式用H2 AZ-H2 B二聚体取代预先存在的核小体H2 A-H2 B二聚体。NuA 4乙酰化组蛋白H4尾部并调节转录、细胞周期进程和DNA修复;在体外它也乙酰化组蛋白H2 A。在高等生物中，TIP 60可能整合NuA 4和SWR 1功能，调节转录、DNA损伤反应、细胞生长控制和凋亡。
SWR1 regulates transcription and is also involved in deposition of histone H2AZ, chromosome stability, and cell-cycle checkpoint adaptation. In vitro it can replace pre-existing nucleosomal H2A-H2B dimers with H2AZ-H2B dimers in an ATP-dependent manner. NuA4 acetylates histone H4 tails and regulates transcription, cell-cycle progression, and DNA repair; in vitro it also acetylates histone H2A. In higher organisms, TIP60 may integrate both NuA4 and SWR1 functions regulating transcription, the DNA-damage response, cellular growth control, and apoptosis.