Inducible nitric oxide synthase regulates production of isoprostanes in vivo during chlamydial genital infection in mice.
Inducible nitric oxide synthase regulates production of isoprostanes in vivo during chlamydial genital infection in mice.
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诱导型一氧化氮合酶在小鼠衣原体生殖器感染期间调节体内异前列腺素的产生。
DOI：
10.1128/iai.71.12.7183-7187.2003
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发表时间：
2003
影响因子：
3.1
通讯作者：
Morrow,JD
中科院分区：
文献类型：
--
作者：
Ramsey,KH;Sigar,IM;Rana,SV;Gupta,J;Holland,SM;Byrne,GI;Morrow,JD
小鼠生殖道衣原体感染后，尿亚硝酸盐和氧化应激指标f2 -异前列腺素升高。白细胞氧化酶缺陷小鼠的尿亚硝酸盐和f2 -异前列腺素水平升高。抑制诱导型一氧化氮合酶可减少异前列腺素排泄。我们得出结论，在小鼠衣原体生殖器感染过程中，氮自由基诱导f2 -异前列腺素的产生和排泄。
Urinary nitrite and F2-isoprostanes, an index of oxidant stress, were elevated during chlamydial genital infection of mice. Enhancement of urinary nitrite and F2-isoprostanes was observed in phagocyte oxidase-deficient mice. Inhibition of inducible nitric oxide synthase reduced isoprostane excretion. We conclude that nitrogen radicals induce F2-isoprostane production and excretion during murine chlamydial genital infection.