Body Temperature-Triggered Shape-Memory Effect via Toughening Sustainable Poly(propylene carbonate) with Thermoplastic Polyurethane: toward Potential Application of Biomedical Stents
Body Temperature-Triggered Shape-Memory Effect via Toughening Sustainable Poly(propylene carbonate) with Thermoplastic Polyurethane: toward Potential Application of Biomedical Stents
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通过用热塑性聚氨酯增韧可持续聚碳酸亚丙酯来实现体温触发的形状记忆效应：生物医学支架的潜在应用
DOI：
10.1021/acssuschemeng.9b06080
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发表时间：
2020-01-27
影响因子：
8.4
通讯作者：
Guo, Shaoyun
中科院分区：
文献类型：
--
作者：
Zeng, Bingbing;Li, Ying;Guo, Shaoyun
采用热塑性聚氨酯（TPU）增韧可持续聚碳酸亚丙酯（PPC）制备了体温触发的形状记忆高分子材料。通过熔融共混的方式加入TPU后，PPC的延展性显著提高，形状回复性提高，但形状固定性变差。值得注意的是，共混物含有50重量%的TPU（PT50）呈现出最佳的形状记忆效应（SME）与平衡的形状恢复和形状固定性能，因为形成的共连续结构促进PPC和TPU之间的协同作用。此外，PT50样品不仅在形状恢复率（类似于95.0%恢复率）方面，而且在恢复速度和恢复应力方面都表现出显著的改善，这使得其在实际应用时能够实现优异的SME。在加工成螺旋状支架后，PT50在37 ℃下仍表现出快速响应，仅在20 s内就能实现有效的自扩张。此外，血液和细胞相容性测试结果显示PT50具有良好的生物相容性，进一步证明了该材料在生物医学支架开发方面的巨大潜力。
Shape-memory polymeric materials triggered by body temperature were fabricated via toughening sustainable poly(propylene carbonate) (PPC) with thermoplastic polyurethane (TPU). With an addition of TPU through melt blending, the ductility of PPC was dramatically enhanced, leading to the increase of shape recoverability but a deterioration of shape fixity. Remarkably, the blend containing 50 wt % TPU (PT50) presented the optimal shape-memory effect (SME) with balanced shape recovery and shape fixation performances because of the formation of the co-continuous structure promoting the synergy between PPC and TPU. Moreover, the PT50 sample exhibited significant improvement in not only the shape recovery ratio (similar to 95.0% recovery) but also the recovery speed and recovery stress, which enabled it to achieve an excellent SME when applied in practical use. After processed into a spiral-like stent, PT50 still showed a fast response to 37 degrees C, giving an efficient self-expansion within only 20 s. Besides, the blood and cell compatibility testing results revealed the good biocompatibility of PT50, further demonstrating the great potential of this material for development of biomedical stents.