The role of STIM1 and SOCE in smooth muscle contractility.
The role of STIM1 and SOCE in smooth muscle contractility.
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DOI：
10.1016/j.ceca.2017.02.007
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发表时间：
2017-05
期刊：
影响因子：
4
通讯作者：
Rosenberg PB
中科院分区：
文献类型：
--
作者：
Feldman CH;Grotegut CA;Rosenberg PB
收缩是骨骼肌、心肌和平滑肌的中心特征;这种独特的特征在很大程度上依赖于钙（Ca 2+）信号传导，因此维持内部Ca 2+储存。基质相互作用分子1（Stromal interaction molecule 1，STIM 1）是一种单通道跨膜蛋白，作为钙离子传感器，在细胞膜上激活钙库操纵的钙通道（SOCC），以响应肌浆网内钙库的耗竭。STIM 1最初的特点是在非兴奋性细胞;然而，来自动物模型和人类突变的证据表明，STIM 1在调节Ca 2+稳态兴奋性组织中的作用。STIM 1依赖性SOCE在持续收缩的组织中特别重要，这使我们相信STIM 1可能在平滑肌收缩中发挥作用。迄今为止，STIM 1在平滑肌中的作用尚不清楚。在这篇综述中，我们提供了一个简短的概述STIM 1依赖的SOCE在横纹肌中的作用，并建立了知识，以调查是否STIM 1有助于平滑肌收缩。最后，我们讨论了翻译的影响，在治疗平滑肌疾病的靶向STIM 1。
Contraction is a central feature for skeletal, cardiac and smooth muscle; this unique feature is largely dependent on calcium (Ca2+) signaling and therefore maintenance of internal Ca2+ stores. Stromal interaction molecule 1 (STIM1) is a single-pass transmembrane protein that functions as a Ca2+ sensor for the activation store-operated calcium channels (SOCCs) on the plasma membrane in response to depleted internal sarco(endo)plasmic (S/ER) reticulum Ca2+ stores. STIM1 was initially characterized in nonexcitable cells; however, evidence from both animal models and human mutations suggests a role for STIM1 in modulating Ca2+ homeostasis in excitable tissues as well. STIM1-dependent SOCE is particularly important in tissues undergoing sustained contraction, leading us to believe STIM1 may play a role in smooth muscle contraction. To date, the role of STIM1 in smooth muscle is unknown. In this review, we provide a brief overview of the role of STIM1-dependent SOCE in striated muscle and build off that knowledge to investigate whether STIM1 contributes to smooth muscle contractility. We conclude by discussing the translational implications of targeting STIM1 in the treatment of smooth muscle disorders.
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