Optical coherence tomography in paediatric glaucoma: time domain versus spectral domain
Optical coherence tomography in paediatric glaucoma: time domain versus spectral domain
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DOI：
10.1136/bjophthalmol-2012-302648
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发表时间：
2013-07-01
影响因子：
4.1
通讯作者：
El-dairi, Mays
中科院分区：
文献类型：
--
作者：
Ghasia, Fatema F.;Freedman, Sharon F.;El-dairi, Mays
背景/目标 谱域 (SD)-光学相干断层扫描 (OCT) 可以跟踪眼球运动，比时域 (TD)-OCT 具有更快的采集时间和更高的分辨率。本研究的目的是评估 SD-OCT 在儿童青光眼中的效用，并确定其与 TD-OCT 的一致性。方法对杜克大学儿童青光眼诊所接受 SD-OCT（Spectralis，海德堡工程公司，德国）的儿童进行回顾性和前瞻性鉴定。比较四组的视乳头周围视网膜神经纤维层 (RNFL) 以及黄斑厚度和体积 (MV)：正常眼、生理性拔罐眼（C:D >0.5 和 21）。将 SD-OCT 值与 TD-OCT（OCT-3，Carl-Zeiss-Meditec，都柏林，加利福尼亚州）值在使用两种仪器进行当天扫描的受试者子集中进行比较。排除患有神经系统疾病、屈光不正 >+/- 5D、假晶状体眼和早产的儿童。 结果 纳入的 83 名儿童的 83 只眼睛，平均年龄 11.9 +/- 4.2 岁。平均 RNFL 厚度和 MV 的 SD-OCT 测量结果在正常人 (n=24)、生理杯形 (n=31)、轻度 (n=15) 与重度青光眼 (n=13) 之间存在差异：（RNFL：分别为 104 +/- 9、99 +/- 6、98 +/- 9 vs62 +/- 18 μm，p
Background/aims Spectral-domain (SD)- Optical Coherence Tomography (OCT) can track eye movements, has faster acquisition time and higher resolution than time-domain(TD)-OCT. The aim of the study was to assess the utility of SD-OCT in paediatric glaucoma and determine its agreement with TD-OCT.Methods Children who had SD-OCT(Spectralis, Heidelberg-Engineering, Germany) were retrospectively and prospectively identified from Duke paediatric glaucoma clinic. The peripapillary retinal nerve fibre layer (RNFL) and macular thickness and volume (MV) were compared amongst four groups: normal eyes, eyes with physiologic cupping (C:D >0.5 and 21). SD-OCT values were compared to TD-OCT(OCT-3, Carl-Zeiss-Meditec, Dublin, CA) values in a subset of subjects who had same day scans using both instruments. Children with neurologic disorders, refractive error >+/- 5D, pseudophakia and prematurity were excluded.Results Included were 83 eyes of 83 children, mean age 11.9 +/- 4.2 years. SD-OCT measurements of average RNFL thickness and MV differed among normals(n=24), physiologically cupped (n=31), mild (n=15) versus severe glaucoma (n=13): (RNFL: 104 +/- 9, 99 +/- 6, 98 +/- 9 vs62 +/- 18 mu m, respectively, p