APOL1-associated kidney disease in northern Nigerians with treated HIV infection.
APOL1-associated kidney disease in northern Nigerians with treated HIV infection.
复制标题
DOI：
10.1016/j.kint.2021.04.023
复制
发表时间：
2021-07
影响因子：
19.6
通讯作者：
Freedman, Barry I.
中科院分区：
文献类型：
--
作者：
Olabisi, Opeyemi A.;Freedman, Barry I.
载脂蛋白L1（APOL 1）高危基因型与HIV相关性肾病密切相关，抗逆转录病毒治疗可降低HIV相关性肾病的发生率和进展为终末期肾病。Wudil等报道了在尼日利亚北方HIV感染患者中，APOL 1与蛋白尿和估计肾小球滤过率的横断面相关性。包括具有不同APOL 1风险变体频率的多个种族组。总的来说，APOL 1与蛋白尿性慢性肾病相关;然而，与肾病的根本原因和进展率的关系需要进一步研究。
Apolipoprotein L1 (APOL1) high-risk genotypes strongly associate with HIV-associated nephropathy, and antiretroviral therapy reduces the incidence of HIV-associated nephropathy and progression to end-stage kidney disease. Wudil et al. report cross-sectional APOL1 associations with proteinuria and estimated glomerular filtration rate in a northern Nigerian sample with HIV infection on antiretroviral therapy. Multiple ethnic groups with different APOL1 risk variant frequencies were included. Overall, APOL1 was associated with proteinuric chronic kidney disease; however, relationships with underlying causes of nephropathy and progression rates require further study.
登录
查看更多内容
影响因子：
13.6
作者：
Kopp, Jeffrey B.;Nelson, George W.;Winkler, Cheryl A.
通讯作者：
Winkler, Cheryl A.
影响因子：
13.2
作者：
Freedman, BI;Soucie, JM;Pegram, S
通讯作者：
Pegram, S
影响因子：
19.6
作者：
PARDO, V;MENESES, R;BOURGOIGNIE, JJ
通讯作者：
BOURGOIGNIE, JJ
影响因子：
9.8
作者：
Ko, Wen-Ya;Rajan, Prianka;Tishkoff, Sarah A.
通讯作者：
Tishkoff, Sarah A.
影响因子：
158.5
作者：
RAO, TKS;FILIPPONE, EJ;FRIEDMAN, EA
通讯作者：
FRIEDMAN, EA