NO INHIBITIONS - ANTIMICROBIAL PROPERTIES OF NITRIC-OXIDE
NO INHIBITIONS - ANTIMICROBIAL PROPERTIES OF NITRIC-OXIDE
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DOI：
10.1093/clinids/21.supplement_2.s162
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发表时间：
1995-10-01
影响因子：
11.8
通讯作者：
FANG, FC
中科院分区：
文献类型：
--
作者：
DEGROOTE, MA;FANG, FC
过去十年，人们对简单分子一氧化氮（NO）作为血管扩张剂、神经递质和抗菌剂的兴趣爆发了。 NO 和其他活性氮中间体对多种病原微生物表现出细胞抑制或杀细胞活性。哺乳动物细胞，包括人类细胞，对炎症刺激作出反应，组成型和诱导型产生一氧化氮。本综述将简要概述目前有关 NO 抗菌活性的知识以及该活性在感染中可能的重要性，特别是对于细胞内病原体。
The past decade has witnessed a veritable explosion of interest in the simple molecule nitric oxide (NO) as a vasodilator, neurotransmitter, and antimicrobial agent. NO and other reactive nitrogen intermediates exhibit cytostatic or cytocidal activity against a remarkable breadth of pathogenic microorganisms. Mammalian cells, including human cells, produce nitric oxide both constitutively and inducibly in response to inflammatory stimuli. This review will provide a brief overview of current knowledge regarding the antimicrobial activity of NO and the possible importance of this activity in infection, particularly with regard to intracellular pathogens.