Clinicopathologic and molecular analysis of disseminated appendiceal mucinous neoplasms: identification of factors predicting survival and proposed criteria for a three-tiered assessment of tumor grade
Clinicopathologic and molecular analysis of disseminated appendiceal mucinous neoplasms: identification of factors predicting survival and proposed criteria for a three-tiered assessment of tumor grade
复制标题
DOI：
10.1038/modpathol.2014.37
复制
发表时间：
2014-11-01
期刊：
影响因子：
7.5
通讯作者：
Pai, Reetesh K.
中科院分区：
文献类型：
--
作者：
Davison, Jon M.;Choudry, Haroon A.;Pai, Reetesh K.
以往的研究表明，播散性粘液性阑尾肿瘤的预后高度依赖于肿瘤的分级。考虑到这一点，第7版美国癌症联合委员会（AJCC）分期系统现在纳入了一个三级分级系统，用于粘液性阑尾肿瘤的预后分期。然而，分级标准没有得到很好的描述。为了解决这个问题，我们评估了2004年至2012年在我们机构治疗的151例广泛播散性阑尾粘液性瘤变患者的219例临床病理和分子特征。在单变量分析中，我们确定了与总生存率较差相关的组织学特征：破坏性浸润、高细胞学分级、高肿瘤细胞构成、血管淋巴管浸润、神经周围浸润和印戒细胞成分（均P
Previous studies have demonstrated that the prognosis of disseminated mucinous appendiceal neoplasms is highly dependent upon tumor grade. Reflecting this, the 7th edition of the American Joint Committee on Cancer (AJCC) staging system now incorporates a three-tier grading system for prognostic staging of mucinous appendiceal tumors. However, the grading criteria are not well described. In order to address this issue, we evaluated clinicopathologic and molecular features of 219 cases from 151 patients with widely disseminated appendiceal mucinous neoplasia treated at our institution between 2004 and 2012. We identified histologic features that were associated with worse overall survival on univariate analysis: destructive invasion, high cytologic grade, high tumor cellularity, angiolymphatic invasion, perineural invasion, and signet ring cell component (all with P