High frequency of calcinosis in juvenile dermatomyositis: a risk factor study
High frequency of calcinosis in juvenile dermatomyositis: a risk factor study
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DOI：
10.1590/s0482-50042012000400007
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发表时间：
2012-08-01
影响因子：
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通讯作者：
Terreri, Maria Teresa R. A.
中科院分区：
文献类型：
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作者：
Clemente, Gleice;Piotto, Daniela Gerent Petry;Terreri, Maria Teresa R. A.
目的：探讨青少年皮肌炎患者钙质沉着的发生频率及其可能的危险因素。方法：回顾34例患者的病历，重点分析以下特点：人口统计学、临床和实验室资料；处理方式；坚持治疗；病程（单环、慢性和多环）；以及疾病的严重程度。患者分为以下两组：发生钙质沉着症的患者（随访6个月前和随访6个月后）和未发生钙质沉着症的患者。27例患者接受了两次甲襞毛细血管镜检查（NFC），当发现硬皮病模式时，认为其改变了。结果：34例患者平均出现症状年龄为6.5岁，至确诊时间为1.2岁，女性占70%。一半的患者有单环病程，只有14.7%的患者有严重的血管炎。近90%的NFC患者在第一次评估中出现变化，74%的患者在第二次评估中出现变化，两次评估之间的平均间隔为1.6年。钙质沉着16例（47.1%）。未观察到所分析的变量与钙质沉着症的发展之间的关联。结论：本研究未发现钙质沉着症的危险因素，尽管在研究的半数青少年皮肌炎患者中发现了这种并发症。
Objective: To assess the frequency of calcinosis in patients with juvenile dermatomyositis, and the possible risk factors for that manifestation. Methods: Medical record review of 34 patients, with an emphasis on the following characteristics: demographic, clinical and laboratory data; type of treatment; adherence to treatment; disease course (monocyclic, chronic and polycyclic); and disease severity. Patients were divided into two groups as follows: those who developed calcinosis (up to the sixth month of follow-up and after six months of follow-up) and those who did not develop calcinosis. Twenty-seven patients underwent two nailfold capillaroscopies (NFC), which were considered altered when the scleroderma pattern was found. Results: The mean age of symptom onset of the 34 patients was 6.5 years, the time until diagnosis was 1.2 years, and 70% were females. Half of the patients had a monocyclic disease course, and only 14.7% had severe vasculitis. Almost 90% of the patients undergoing NFC showed a change on the first assessment, 74% showed a change on the second assessment, and the mean interval between both assessments was 1.6 year. Calcinosis was evidenced in 16 (47.1%) patients. No association was observed between the variables analyzed and the development of calcinosis. Conclusion: No risk factors for calcinosis were identified in this study, although that complication was found in half of the patients with juvenile dermatomyositis studied.