Immunoscore and Immunoprofiling in cancer: an update from the melanoma and immunotherapy bridge 2015.
Immunoscore and Immunoprofiling in cancer: an update from the melanoma and immunotherapy bridge 2015.
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DOI：
10.1186/s12967-016-1029-z
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发表时间：
2016-09-20
影响因子：
7.4
通讯作者：
Capone M
中科院分区：
文献类型：
--
作者：
Galon J;Fox BA;Bifulco CB;Masucci G;Rau T;Botti G;Marincola FM;Ciliberto G;Pages F;Ascierto PA;Capone M
第五届“黑色素瘤桥梁会议”于2015年12月1日至5日在那不勒斯举行。本次会议讨论的主要议题是：分子和免疫进展，免疫疗法和联合疗法，肿瘤微环境和生物标志物和免疫评分。癌症的自然史涉及肿瘤与宿主免疫系统之间的相互作用。肿瘤部位的免疫浸润可指示宿主反应。肿瘤中免疫细胞浸润的水平与患者的临床结果之间显示出显著的相关性。此外，令人难以置信的进展来自突变编码的肿瘤新抗原的发现。事实上，随着肿瘤的生长，它们会获得能够影响患者对免疫检查点抑制剂反应的突变。已经证明，晚期NSCLC和黑色素瘤患者对PD-1和CTLA-4阻断的敏感性在富含克隆新抗原的肿瘤中增强。前面的路还很长，但对免疫逃逸机制的了解，对肿瘤新抗原和肿瘤微环境的研究以及新的免疫治疗策略的开发，将使癌症成为越来越可治疗的疾病。
The fifth “Melanoma Bridge Meeting” took place in Naples, December 1–5th, 2015. The main topics discussed at this meeting were: Molecular and Immuno advances, Immunotherapies and Combination Therapies, Tumor Microenvironment and Biomarkers and Immunoscore. The natural history of cancer involves interactions between the tumor and the immune system of the host. The immune infiltration at the tumor site may be indicative of host response. Significant correlations were shown between the levels of immune cell infiltration in tumors and patient’s clinical outcome. Moreover, incredible progress comes from the discovery of mutation-encoded tumor neoantigens. In fact, as tumors grow, they acquire mutations that are able to influence the response of patients to immune checkpoint inhibitors. It has been demonstrated that sensitivity to PD-1 and CTLA-4 blockade in patients with advanced NSCLC and melanoma was enhanced in tumors enriched for clonal neoantigens. The road ahead is still very long, but the knowledge of the mechanisms of immune escape, the study of tumor neo-antigens as well as of tumor microenvironment and the development of new immunotherapy strategies, will make cancer a more and more treatable disease.
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影响因子：
7.4
作者：
Koelzer VH;Lugli A;Dawson H;Hädrich M;Berger MD;Borner M;Mallaev M;Galván JA;Amsler J;Schnüriger B;Zlobec I;Inderbitzin D
通讯作者：
Inderbitzin D
影响因子：
64.8
作者：
Herbst RS;Soria JC;Kowanetz M;Fine GD;Hamid O;Gordon MS;Sosman JA;McDermott DF;Powderly JD;Gettinger SN;Kohrt HE;Horn L;Lawrence DP;Rost S;Leabman M;Xiao Y;Mokatrin A;Koeppen H;Hegde PS;Mellman I;Chen DS;Hodi FS
通讯作者：
Hodi FS
影响因子：
7.2
作者：
Berghoff, Anna S.;Fuchs, Elisabeth;Preusser, Matthias
通讯作者：
Preusser, Matthias
影响因子：
17.1
作者：
Mlecnik, Bernhard;Bindea, Gabriela;Galon, Jerome
通讯作者：
Galon, Jerome
影响因子：
7.3
作者：
Galon, Jerome;Mlecnik, Bernhard;Bindea, Gabriela;Angell, Helen K.;Berger, Anne;Lagorce, Christine;Lugli, Alessandro;Zlobec, Inti;Hartmann, Arndt;Bifulco, Carlo;Nagtegaal, Iris D.;Palmqvist, Richard;Masucci, Giuseppe V.;Botti, Gerardo;Tatangelo, Fabiana;Delrio, Paolo;Maio, Michele;Laghi, Luigi;Grizzi, Fabio;Asslaber, Martin;D'Arrigo, Corrado;Vidal-Vanaclocha, Fernando;Zavadova, Eva;Chouchane, Lotfi;Ohashi, Pamela S.;Hafezi-Bakhtiari, Sara;Wouters, Bradly G.;Roehrl, Michael;Nguyen, Linh;Kawakami, Yutaka;Hazama, Shoichi;Okuno, Kiyotaka;Ogino, Shuji;Gibbs, Peter;Waring, Paul;Sato, Noriyuki;Torigoe, Toshihiko;Itoh, Kyogo;Patel, Prabhu S.;Shukla, Shilin N.;Wang, Yili;Kopetz, Scott;Sinicrope, Frank A.;Scripcariu, Viorel;Ascierto, Paolo A.;Marincola, Francesco M.;Fox, Bernard A.;Pages, Franck
通讯作者：
Pages, Franck