Carnosine is neuroprotective against permanent focal cerebral ischemia in mice
Carnosine is neuroprotective against permanent focal cerebral ischemia in mice
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DOI：
10.1161/strokeaha.107.488502
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发表时间：
2007-11-01
期刊：
影响因子：
8.3
通讯作者：
Majid, Arshad
中科院分区：
文献类型：
--
作者：
Rajanikant, G. K.;Zemke, Daniel;Majid, Arshad
背景和目的 - 肌肽是一种天然存在的二肽，具有多种神经保护特性。此外，它在高剂量下具有良好的耐受性，且副作用最小。本研究的目的是确定肌肽在永久性局灶性脑缺血中是否具有神经保护作用，并确定神经保护的潜在机制。方法-我们研究了肌肽在永久性局灶性脑缺血小鼠模型中的功效。研究了肌肽对神经元损伤和梗塞形成、内源性抗氧化状态和基质金属蛋白酶活性的影响。结果-在诱导缺血之前和之后的时间点施用肌肽可显着减少梗塞面积和神经元损伤。肌肽还降低缺血脑中的活性氧水平，保持正常的谷胱甘肽水平，并降低基质金属蛋白酶蛋白水平和活性。结论 - 肌肽在局灶性脑缺血中具有神经保护作用，并且似乎影响缺血发作后激活的有害病理过程。
Background and Purpose - Carnosine is a naturally occurring dipeptide with multiple neuroprotective properties. In addition, it is well tolerated in high doses with minimal side effects. The purposes of this study were to determine whether carnosine is neuroprotective in permanent focal cerebral ischemia and to determine potential mechanisms of neuroprotection.Methods - We investigated the efficacy of carnosine in a mouse model of permanent focal cerebral ischemia. The effects of carnosine were investigated with respect to neuronal damage and infarct formation, endogenous antioxidant status, and matrix metalloproteinase activity.Results - Carnosine significantly decreased infarct size and neuronal damage when administered at time points both before and after the induction of ischemia. Carnosine also decreased reactive oxygen species levels in the ischemic brain, preserved normal glutathione levels, and decreased matrix metalloproteinase protein levels and activity.Conclusions - Carnosine is neuroprotective in focal cerebral ischemia and appears to influence deleterious pathological processes that are activated after the onset of ischemia.