Intravitreal large-cell lymphoma.
Intravitreal large-cell lymphoma.
复制标题
玻璃体内大细胞淋巴瘤。
DOI：
10.1016/s0025-6196(12)62276-9
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发表时间：
1993
影响因子：
8.9
通讯作者：
Bolling,JP
中科院分区：
文献类型：
--
作者：
Buettner,H;Bolling,JP
大细胞(非霍奇金)淋巴瘤可发生在眼内，表现为细胞渗入玻璃体、葡萄膜束(脉络膜)、视网膜或视神经。淋巴瘤性病变可能仅限于眼睛，但也经常与中枢神经系统的损害有关。眼睛受累可能比中枢神经系统受累早几个月，在某些情况下，甚至几年。眼大细胞淋巴瘤约80%是双侧的，但通常是不对称的。眼部大细胞淋巴瘤患者的平均年龄为60岁，女性受到影响的频率几乎是男性的两倍。玻璃体内大细胞淋巴瘤可表现为大的玻璃灰色细胞或细胞团的浸润性，它可模仿葡萄膜炎或眼睛的其他炎症和感染情况。诊断基于细胞学和免疫细胞化学研究，通过平坦部抽吸或玻璃体切割术获得玻璃体活检标本。眼部和中枢神经系统放射治疗的进展，辅以皮质类固醇、鞘内和静脉注射化疗药物，改善了大细胞淋巴瘤患者的不良预后。
Large-cell (non-Hodgkin's) lymphoma may occur in the eye as a cellular infiltrate in the vitreous, uveal tract (choroid), retina, or optic nerve. Lymphomatous involvement may be limited to the eye but also is frequently associated with lesions of the central nervous system. Ocular involvement may precede involvement of the central nervous system by months or, in some cases, years. Ocular large-cell lymphoma is bilateral in approximately 80% of cases but often is asymmetric. The mean age of patients with ocular large-cell lymphoma is 60 years, and women are affected almost twice as often as men. Intravitreal large-cell lymphoma may manifest as an infiltrate of large glassy-gray cells or clusters of cells, and it may mimic uveitis or other inflammatory and infectious conditions of the eye. The diagnosis is based on cytologic and immunocytochemical studies of a vitreous biopsy specimen obtained by aspiration or by vitrectomy through the pars plana. Advances in irradiation of the eyes and the central nervous system, supplemented with corticosteroids and intrathecally and intravenously administered chemotherapeutic agents, have resulted in improvement of the dismal prognosis for patients with large-cell lymphoma.