Design, synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antifungal and anticancer agents
Design, synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antifungal and anticancer agents
复制标题
DOI：
10.1016/j.bmcl.2004.01.002
复制
发表时间：
2004-03-08
影响因子：
2.7
通讯作者：
Yadav, DB
中科院分区：
文献类型：
--
作者：
Tandon, VK;Chhor, RB;Yadav, DB
合成了一系列 1,4-萘醌衍生物，并测试了针对多种真菌疾病致病物种和 Walker 256 癌细胞系的抗真菌和抗肿瘤活性。结果表明，化合物8a、e和11b具有显着的抗真菌特性，而7b和f被发现对Walker 256癌细胞系具有活性。此外，7c和11a显示出对来自Rauscher鼠白血病病毒的逆转录酶的抑制作用。 (C) 2004 Elsevier Ltd. 保留所有权利。
A series of 1,4-naphthoquinone derivatives were synthesized and tested for antifungal and antitumor activity against a number of fungal disease causative species and Walker 256 carcinoma cell lines. The results show that the compounds 8a,e and 11b possess pronounced antifungal proifile where as 7b and f were found to be active against Walker 256 carcinoma cell lines. Moreover 7c and 11a showed inhibitory effect against reverse transcriptase enzyme from Rauscher Murine Leukemia Virus. (C) 2004 Elsevier Ltd. All rights reserved.