The not-so-simple process of sickle cell vasoocclusion
The not-so-simple process of sickle cell vasoocclusion
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DOI：
10.1080/10739680490278277
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发表时间：
2004-03-01
期刊：
影响因子：
2.4
通讯作者：
Embury, SH
中科院分区：
文献类型：
--
作者：
Embury, SH
镰状细胞病作为单基因遗传性疾病的传统概念是基于聚合的病理生理学完全理解的，比临床观察所允许的更简单。聚合的决定因素的详细解释可以计数，但这些并不能解释镰状细胞病的所有方面。也不能把镰状细胞病过程中的所有扰动都算作聚合的决定因素。已经外推来描述临床疾病的基于聚合的理论通常与临床现实不相同。虽然当代的理解镰状细胞病理生理学已被描述为疯狂的传统聚合为基础的理解，越来越多的偶像崇拜，看似疯狂的概念定期提供重要的新的理解镰状细胞疾病。当代研究人员面临的主要挑战之一是以一种可以被其他人理解的方式描述新的科学见解，特别是那些不愿意在解释镰状细胞病的相互依赖的过程中提供聚合独立发现的有效性的人。
Traditional concepts of sickle cell disease as a monogenically inherited disorder that is understood completely on the basis of polymerization based pathophysiology are more simple that what clinical observations allow. Detailed explications of the determinants of polymerization can be counted, but these do not account for all aspects of sickle cell disease. Neither can all perturbations that count in the course of sickle cell disease be counted as determinants of polymerization. The polymerization based theory that has been extrapolated to describe clinical disease often is not identical to clinical reality. Although contemporary understandings of sickle cell pathophysiology have been described as crazy by those bound to traditional polymerization based understandings, increasingly iconoclastic, seemingly crazy notions are regularly providing important new understandings of sickle cell disease. One of the major challenges to contemporary investigators is to describe new scientific insights in a way that can be understood by others, particularly those reluctant to afford polymerization independent discoveries validity among the interdependent processes that account for sickle cell disease.