Assessment of predictions submitted for the CASP6 comparative modeling category
Assessment of predictions submitted for the CASP6 comparative modeling category
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DOI：
10.1002/prot.20720
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发表时间：
2005-01-01
影响因子：
2.9
通讯作者：
Valencia, A
中科院分区：
文献类型：
--
作者：
Tress, M;Ezkurdia, L;Valencia, A
在这里，我们提出了蛋白质结构预测的关键评估（CASP6）比较建模类别的秋季概述。通过对预测结构和实验结构进行详细的数值比较，对43个比较模型目标的预测精度进行了评估。使用模型主干质量和结构对准精度的标准测量方法进行评估，突出了少数具有突出预测的组，这些发现得到了统计比较的支持。我们能够对侧链接触预测和侧链旋转精度进行评估，其中一组在统计上有更好的预测。我们还评估了结构分化区和重要生物学位点的预测质量。有趣的是，我们发现预测者对这些重要功能区域的预测并不比其他区域准确。此外，我们还研究了预测者构建改进结构模板的模型的能力，并通过与先前CASP实验的比较得出了一些初步结论。
Here we present a fall overview of the Critical Assessment of Protein Structure Prediction (CASP6) comparative modeling category. Prediction accuracy for the 43 comparative modeling targets was assessed through detailed numerical comparisons between predicted and experimental structures. Assessments using standard measures for model backbone quality and structural alignment accuracy highlighted a small number of groups with stand out predictions and these findings were backed up by statistical comparisons. We were able to carry out evaluations of side-chain contacts predictions and side-chain rotamer accuracy, for which one group turned out to have statistically better predictions. We also assessed the prediction quality of structurally divergent regions and biologically important sites. Interestingly we were able to show that predictors were not predicting these important functional regions with any greater accuracy than the rest of the structure. In addition we investigated the ability of predictors to build models that improve on the structural template and reached some tentative conclusions from comparisons with the previous CASP experiment.