Distinct form I, II, III, and IV Rubisco proteins from the three kingdoms of life provide clues about Rubisco evolution and structure/function relationships
Distinct form I, II, III, and IV Rubisco proteins from the three kingdoms of life provide clues about Rubisco evolution and structure/function relationships
复制标题
DOI：
10.1093/jxb/erm361
复制
发表时间：
2008-05-01
影响因子：
6.9
通讯作者：
Scott, Stephanie S.
中科院分区：
文献类型：
--
作者：
Tabita, F. Robert;Satagopan, Sriram;Scott, Stephanie S.
核酮糖1，5-二磷酸羧化酶/加氧酶（Rubisco）在自然界中有四种形式。I型、II型和III型催化1，5-二磷酸核酮糖的羧化和氧化，而IV型，也称为Rubisco样蛋白（RLP），不催化这些反应。RLP似乎有六个不同的分支。虽然在一级序列和三级结构水平上与真正的Rubisco蛋白相关，但已知来自这些进化枝中的两个的RLP在细胞中执行其他功能。I型、II型和III型Rubisco沿着IV型（RLP）被认为是从原始古细菌Rubisco进化而来的。结构/功能的研究与古菌III型（产甲烷菌）和I型（蓝藻）Rubisco已确定的残基，似乎是专门参与与分子氧的相互作用。一个特定的区域的所有形式I，II和III Rubisco被确定为是重要的这些相互作用。
There are four forms of ribulose 1,5-bisphosphate carboxylase/oxygenase (Rubisco) found in nature. Forms I, II, and III catalyse the carboxylation and oxygenation of ribulose 1,5-bisphosphate, while form IV, also called the Rubisco-like protein (RLP), does not catalyse either of these reactions. There appear to be six different clades of RLP. Although related to bona fide Rubisco proteins at the primary sequence and tertiary structure levels, RLP from two of these clades is known to perform other functions in the cell. Forms I, II, and III Rubisco, along with form IV (RLP), are thought to have evolved from a primordial archaeal Rubisco. Structure/function studies with both archaeal form III (methanogen) and form I (cyanobacterial) Rubisco have identified residues that appear to be specifically involved with interactions with molecular oxygen. A specific region of all form I, II, and III Rubisco was identified as being important for these interactions.