Selectivity enhancement in the Rh(II)-Catalyzed cyclopropanation of styrene with (Silanyloxyvinyl)diazoacetates
Selectivity enhancement in the Rh(II)-Catalyzed cyclopropanation of styrene with (Silanyloxyvinyl)diazoacetates
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DOI：
10.1021/ol049554n
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发表时间：
2004-05-27
期刊：
影响因子：
5.2
通讯作者：
Flack, HD
中科院分区：
文献类型：
--
作者：
Muller, P;Bernardinelli, G;Flack, HD
在手性Rh(II)催化剂存在下，(硅氧基乙烯基重氮乙酸酯)与苯乙烯的环丙烷化反应具有优异的非对映选择性和对映选择性。1，8-萘甲酰基保护的氨基酸是这些转化最有效的Rh(II)配体。
The cyclopropanation of styrene with (silanyloxyvinyl)diazoacetates proceeds with exceptional diastereo- and enantioselectivity in the presence of chiral Rh(II) catalysts. 1,8-Naphthoyl-protected amino acids are the most effective Rh(II) ligands for these transformations.