Birth weight and body composition in young adult men - a prospective twin study
Birth weight and body composition in young adult men - a prospective twin study
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DOI：
10.1038/sj.ijo.0801743
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发表时间：
2001-10-01
影响因子：
4.9
通讯作者：
Vlietinck, R
中科院分区：
文献类型：
--
作者：
Loos, RJF;Beunen, G;Vlietinck, R
目的：在控制母体和遗传影响的情况下，评估双胞胎出生体重和成年体成分之间的关系。设计：从东弗兰德斯前瞻性双胞胎调查中随机选择双胞胎，这是一个以人口为基础的历史双胞胎队列。受试者：229对年龄在18到34岁之间的双胞胎中的男性成员，他们参加了产前编程双胞胎研究。测量指标：成人体重、身高、身体质量指数、瘦体重、皮肤褶皱总和、腰臀比。瘦体重、皮肤褶皱总和和腰臀比也根据体重进行了调整。出生时体重最重的双胞胎和体重最轻的双胞胎之间的成人人体测量差异。结果：出生体重每增加kg，体重（4.2 kg）、身高（3.3 cm）、瘦体重（3.1 kg）和较小程度的BMI （0.49 kg /m(2)）增加，而腰臀比（-1.4%）和皮肤褶皱数（-0.11 s.d）在调整体重后下降。在对双胞胎的分析中，出生时较重的双胞胎成年后更高更重，但是，当根据体重调整后，与较轻的双胞胎相比，他的腰臀比较低，皮下脂肪较少，体重更瘦。在同卵双胞胎和异卵双胞胎中，身体组成的对内差异与对内出生体重的差异有关。结论：不良的子宫内环境（以出生体重衡量）与成年后皮下和腹部脂肪增多、瘦体重减少有关。这种关联不受母亲和遗传的影响。然而，我们不能排除影响出生体重和成年身体组成的基因的存在。
OBJECTIVES: To evaluate the association between birth weight and adult body composition in twins, controlling for maternal and genetic influences.DESIGN: Twins were randomly selected from the East Flanders Prospective Twin Survey, a population-based historic twin cohort.SUBJECTS: Male members of 229 twin pairs between 18 and 34y of age who participated in the Prenatal Programming Twin Study.MEASUREMENTS: Adult body mass, height, BMI, lean body mass, sum of skinfolds and waist-to-hip-ratio. Lean body mass, sum of skinfolds and waist-to-hip-ratio were also adjusted for body mass. Intra-pair difference in adult anthropometric measures between the heaviest and the lightest twin at birth.RESULTS: Per kg increase in birth weight, body mass (4.2 kg), height (3.3 cm), lean body mass (3.1 kg) and to a lesser extent BMI (0.49 kg /m(2)) increased, whereas waist-to-hip-ratio (-1.4%) and sum of skinfolds (-0.11 s.d.) decreased, when adjusted for body mass. In a pair-wise analysis, the heavier twin at birth was taller and heavier as an adult, but, when adjusted for body mass, he had a lower waist-to-hip-ratio, less subcutaneous fat, and more lean body mass, compared to his lighter sib. Intra-pair difference in body composition was associated with intra-pair birth weight difference in monozygotic and dizygotic twins.CONCLUSIONS: An adverse intra-uterine environment, as measured by birth weight, is associated with more subcutaneous and abdominal fat and less lean body mass in adulthood. This association is independent of maternal and genetic influences. However, we cannot exclude the existence of genes that act on both birth weight and adult body composition.