HUMAN-LEUKOCYTE ANTIGEN (HLA) DR4 - POSITIVE ASSOCIATION WITH RAPIDLY PROGRESSING PERIODONTITIS
HUMAN-LEUKOCYTE ANTIGEN (HLA) DR4 - POSITIVE ASSOCIATION WITH RAPIDLY PROGRESSING PERIODONTITIS
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DOI：
10.1902/jop.1987.58.9.607
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发表时间：
1987-09-01
影响因子：
4.3
通讯作者：
BRAUTBAR, C
中科院分区：
文献类型：
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作者：
KATZ, J;GOULTSCHIN, J;BRAUTBAR, C
几位作者已经研究了人类白细胞抗原（HLA）决定簇与牙周炎之间的关系，但没有显示任何特定的模式。然而，尚无研究调查 HLA-D 决定簇，该决定簇通常与免疫紊乱和快速进展性牙周炎 (RPP) 相关。将 10 名 RPP 患者的 HLA 谱与健康对照人群 (n = 120) 进行比较。虽然 HLA-A、HLA-B 和 HLA-C 没有发现显着差异，但 HLA-D 组的 HLA-DR4 在 80% 的患者中被发现，而在对照组中只有 38.3%。据报道，类风湿性关节炎 (RA) 患者中 HLA-DR4 的出现频率较高。鉴于之前的报告强调了 RA 和牙周病之间的相似性，这一发现可能具有重要意义。
The relationship between human leukocyte antigens (HLA) determinants and periodontitis has been examined by several authors without showing any particular pattern. However, no study has investigated the HLA-D determinants, which are generally associated with immune disorders, and rapidly progressive periodontitis (RPP). The HLA profile of 10 RPP patients was compared with that of a healthy control population (n = 120). Although no significant difference was found for HLA-A, HLA-B, and HLA-C, HLA-DR4 of the HLA-D group was found in 80% of patients but only in 38.3% of controls. A high frequency of HLA-DR4 has been reported in rheumatoid arthritis (RA) patients. This finding may be significant in light of previous reports highlighting similarities bewteen RA and periodontal disease.