A major genetic locus affecting resistance to infection with murine leukemia viruses. II. Apparent identity to a major locus described for resistance to friend murine leukemia virus.
A major genetic locus affecting resistance to infection with murine leukemia viruses. II. Apparent identity to a major locus described for resistance to friend murine leukemia virus.
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DOI：
10.1084/jem.133.6.1234
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发表时间：
1971-06-01
期刊：
影响因子：
--
通讯作者：
Lilly F
中科院分区：
文献类型：
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作者：
Pincus T;Rowe WP;Lilly F
N-B基因座影响组织培养感染性与自然发生的小鼠白血病病毒似乎是相同的Fv-1基因座描述的敏感性朋友白血病病毒。组织培养研究的结果与体内研究的结果平行，表明F-S病毒是N嗜性的，F-B病毒是NB嗜性的。对Fv-1敏感的近交系和部分同源系小鼠品系显示N型敏感性;对Fv-1耐药的品系显示B型敏感性。Fv-2基因座在组织培养中似乎没有发挥显著作用。对N-B型的了解有助于预测Fv-1的敏感性。
The N-B locus affecting tissue culture infectivity with naturally occurring murine leukemia viruses appears to be identical to the Fv-1 locus described for sensitivity to Friend leukemia virus. Results of tissue culture studies were parallel to results of studies in vivo and indicate that the F-S virus is N-tropic and the F-B virus is NB-tropic. Inbred and partially congenic mouse strains sensitive at Fv-1 show N-type sensitivity; strains resistant at Fv-1 show B-type sensitivity. The Fv-2 locus does not appear to exert significant effect in tissue culture. Knowledge of N-B type has been useful in predicting Fv-1 sensitivity.