Kinetic model of whole-body vanadium metabolism: studies in sheep.
Kinetic model of whole-body vanadium metabolism: studies in sheep.
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DOI：
10.1152/ajpregu.1986.251.2.r325
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发表时间：
1986-08
期刊：
影响因子：
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通讯作者：
B. Patterson;S. Hansard;C. B. Ammerman;P. R. Henry;L. Zech;W. Fisher
中科院分区：
文献类型：
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作者：
B. Patterson;S. Hansard;C. B. Ammerman;P. R. Henry;L. Zech;W. Fisher
本文提出了绵羊钒代谢的房室模型。该模型与从饲喂含0或200 ppm补充钒的对照饮食（2.6 ppm钒）的绵羊获得的数据一致。绵羊口服或静脉注射48 V二氧钒。给药后6天监测血液、粪便和尿液放射性。几个新的见解钒代谢的建议和测试对使用该模型的数据。其中一些包括48 V的显著吸收发生在上胃肠道;为了将48 V二氧钒转化为更具生物反应性的物质，体内过程是必要的;在稳态下，上胃肠道和下胃肠道分别含有至少10倍和100倍的钒质量，比血液。在接受0和200 ppm膳食补充钒的动物之间，转运速率常数没有统计学显著差异。该模型的建立将为今后反刍动物钒代谢研究提供参考。
A compartmental model for vanadium metabolism in sheep has been proposed. The model is consistent with data obtained from sheep fed a control diet (2.6 ppm vanadium) containing 0 or 200 ppm supplemental vanadium. Sheep were administered 48V dioxovanadium either orally or intravenously. Blood, feces, and urine radioactivity were monitored for 6 days postdosing. Several new insights regarding vanadium metabolism are suggested and tested against the data using the model. Some of these include significant absorption of 48V occurs from the upper gastrointestinal tract; an in vivo process is necessary in order for 48V dioxovanadium to be converted into a more biologically reactive species; at steady state the upper and lower gastrointestinal tracts contain at least 10- and 100-fold more mass of vanadium, respectively, than does blood. No statistically significant differences in transport rate constants were found between animals receiving 0 and 200 ppm supplemental dietary vanadium. The availability of a model will enable the refinement of future studies regarding vanadium metabolism in the ruminant.