A PROSPECTIVE-STUDY OF OBESITY, LIPIDS, APOLIPOPROTEINS AND ISCHEMIC-HEART-DISEASE IN WOMEN
A PROSPECTIVE-STUDY OF OBESITY, LIPIDS, APOLIPOPROTEINS AND ISCHEMIC-HEART-DISEASE IN WOMEN
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DOI：
10.1016/0021-9150(92)90276-m
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发表时间：
1992-02-01
期刊：
影响因子：
5.3
通讯作者：
SANDERS, TAB
中科院分区：
文献类型：
--
作者：
COLEMAN, MP;KEY, TJA;SANDERS, TAB
该研究的目的是使用嵌套在队列研究中的病例对照研究，检查肥胖、脂质和载脂蛋白与中年女性随后发生缺血性心脏病风险的关系。1977年至1985年期间，在根西岛共招募了3 634名年龄在26-88岁之间的妇女，并通过提取她们的全科医生记录对其进行跟踪调查，直至1986年6月。确定了51例缺血性心脏病（11例心肌梗死，40例心绞痛）。对于每例病例，选择最多4例对照，年龄和招募日期匹配。对照组中每个变量分布的中、上三分之一相对于最低三分之一发生缺血性心脏病的比值比（和线性趋势的双侧P值）分别为：3.0，2.6（0.015）克托莱指数; 3.3，5.1（0.003）;载脂蛋白A-I为0.5，0.6（0.102）;载脂蛋白B为1.8，2.4（0.015）;载脂蛋白（a）为1.3，2.1（0.155）。与克托莱指数和总胆固醇增加相关的风险增加是相互独立的，这些变量与心肌梗死的相关性比心绞痛更强。与血清可替宁，脂肪酸，硫酸脱氢表雄酮和性激素结合球蛋白的风险关系很弱，没有接近统计学意义。
The aim of the study was to examine the relationships of obesity, lipids and apolipoproteins with the risk for subsequent ischaemic heart disease in middle-aged women, using a case-control study nested within a cohort study. A total of 3634 women aged 26-88 were recruited in Guernsey between 1977 and 1985 and followed until June 1986 by abstraction of their general practitioners' records. Fifty-one cases of incident ischaemic heart disease (11 myocardial infarction, 40 angina) were identified. For each case up to 4 controls were selected, matched for age and date at recruitment. Odds ratios for the development of ischaemic heart disease in the middle and upper thirds of the distribution for each variable in the controls, relative to the lowest third (and two-sided P-values for linear trends), were: 3.0, 2.6 (0.015) for Quetelet's index; 3.3, 5.1 (0.003) for total cholesterol; 0.5, 0.6 (0.102) for apolipoprotein A-I; 1.8, 2.4 (0.015) for apolipoprotein B; 1.3, 2.1 (0.155) for apolipoprotein(a). The increased risks associated with increased Quetelet's index and total cholesterol were independent of each other and these variables were more strongly related to myocardial infarction than to angina. The relationships of risk with serum cotinine, fatty acids, dehydroepiandrosterone sulphate and sex hormone binding globulin were weak and did not approach statistical significance.