Early cardiac outcomes following contemporary treatment for childhood acute myeloid leukemia: A north American perspective
Early cardiac outcomes following contemporary treatment for childhood acute myeloid leukemia: A north American perspective
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DOI：
10.1002/pbc.24498
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发表时间：
2013-09-01
影响因子：
3.2
通讯作者：
Freyer, David R.
中科院分区：
文献类型：
--
作者：
Orgel, Etan;Zung, Laura;Freyer, David R.
Background Anthracycline agents are used for treatment of acute myeloid leukemia (AML) but may cause late-onset cardiomyopathy. Current frontline therapy for AML in North America, as reflected in the approach of the Children's Oncology Group (COG) and other pediatric consortia, is adapted from the anthracyline-intensive Medical Research Council (MRC) regimen. The purpose of this study was to describe early post-treatment cardiac function as a potential indicator of acute and long-term risk associated with this approach. Procedure A multi-center retrospective cohort analysis was conducted of AML survivors diagnosed from 2004 to 2009 and treated with MRC-based regimens. Change in left ventricular shortening fraction (LVSF) on echocardiogram was determined from baseline to latest post-treatment/pre-relapse value; associations with potential predictors were examined. Results This cohort of pediatric survivors (n=52) was assessed at a median interval of 13 months from end of treatment. Mean cumulative anthracycline dose was 339 +/- 14mg/m(2). Mean baseline and post-treatment LVSF were 39.3 +/- 0.8% and 35.4 +/- 0.9%, respectively; mean percent change for individuals was -8.4 +/- 2.8% (P
