The developmental origins of adult disease
The developmental origins of adult disease
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DOI：
10.1111/j.1740-8709.2005.00020.x
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发表时间：
2005-07-01
影响因子：
3.4
通讯作者：
Pinal, Catherine
中科院分区：
文献类型：
--
作者：
Gluckman, Peter D.;Hanson, Mark A.;Pinal, Catherine
流行病学和临床观察得出的假设是，成年后罹患某些慢性病的风险不仅受到遗传和成年生活方式因素的影响，还受到生命早期环境因素的影响。这些因素通过发育可塑性和可能的表观遗传修饰过程起作用，并且可以与发育中断区分开来。预测性适应的概念已经发展到解释早期生活事件和后期疾病风险之间的关系。在其基础上，该模型表明胎儿对其出生后环境的期望与实际出生后环境之间的不匹配会导致成年后的疾病风险。这种不匹配加剧了，部分原因是“母体限制”胎儿生长的现象，这隐含地提供了一个人类已经适应的产后营养环境的上限，现在经常被超过。这些实验、临床和概念上的考虑对预防和干预当前流行的儿童肥胖和成人代谢和心血管疾病具有重要意义。
Epidemiological and clinical observations have led to the hypothesis that the risk of developing some chronic diseases in adulthood is influenced not only by genetic and adult lifestyle factors, but also by environmental factors acting in early life. These factors act through the processes of developmental plasticity and possibly epigenetic modification, and can be distinguished from developmental disruption. The concept of predictive adaptation has been developed to explain the relationship between early life events and the risk of later disease. At its base, the model suggests that a mismatch between fetal expectation of its postnatal environment and actual postnatal environment contribute to later adult disease risk. This mismatch is exacerbated, in part, by the phenomenon of 'maternal constraint' on fetal growth, which implicitly provides an upper limit of postnatal nutritional environment that humans have adapted for and is now frequently exceeded. These experimental, clinical and conceptual considerations have important implications for prevention and intervention in the current epidemic of childhood obesity and adult metabolic and cardiovascular disorders.