DIETARY-INTAKE OF FIBER AND DECREASED RISK OF CANCERS OF THE COLON AND RECTUM - EVIDENCE FROM THE COMBINED ANALYSIS OF 13 CASE-CONTROL STUDIES
DIETARY-INTAKE OF FIBER AND DECREASED RISK OF CANCERS OF THE COLON AND RECTUM - EVIDENCE FROM THE COMBINED ANALYSIS OF 13 CASE-CONTROL STUDIES
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DOI：
10.1093/jnci/84.24.1887
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发表时间：
1992-12-16
期刊：
影响因子：
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通讯作者：
ZHENG, S
中科院分区：
文献类型：
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作者：
HOWE, GR;BENITO, E;ZHENG, S
背景：结直肠癌是北美和西欧的一个主要公共卫生问题，在许多以前低风险的国家，结直肠癌的发病率和死亡率正在迅速上升。据推测，增加纤维、维生素 C 和 β 胡萝卜素的摄入量可以降低患结直肠癌的风险。目的：本研究的目的是通过对先前在不同结直肠癌发病率和饮食习惯的人群中进行的 13 项病例对照研究的数据进行综合分析，探讨纤维、维生素 C 和 β-胡萝卜素摄入量对结直肠癌风险的影响。该研究旨在估计汇总数据中的风险，测试各项研究之间关联的一致性，并检查营养素的影响与癌症部位、性别和年龄之间的相互作用。方法：合并5287例结直肠癌病例和10470例无疾病对照受试者的原始数据记录。使用逻辑回归分析来估计纤维、维生素 C 和 β 胡萝卜素摄入量的相对风险和置信区间，并通过分层调整研究、性别和年龄组的影响。结果：随着纤维摄入量的增加，风险降低；与最低五分位数相比，摄入量最高的四个五分位数的相对风险分别为 0.79、0.69、0.63 和 0.53（趋势，P
Background: Colorectal cancer is a major public health problem in both North America and western Europe, and incidence and mortality rates are rapidly increasing in many previously low-risk countries. It has been hypothesized that increased intakes of fiber, vitamin C, and beta carotene could decrease the risk of colorectal cancer. Purpose: The objective of this study was to examine the effects of fiber, vitamin C, and beta-carotene intakes on colorectal cancer risk in a combined analysis of data from 13 case-control studies previously conducted in populations with differing colorectal cancer rates and dietary practices. The study was designed to estimate risks in the pooled data, to test the consistency of the associations across the studies, and to examine interactions of the effects of the nutrients with cancer site, sex, and age. Methods: Original data records for 5287 case subjects with colorectal cancer and 10 470 control subjects without disease were combined. Logistic regression analysis was used to estimate relative risks and confidence intervals for intakes of fiber, vitamin C, and beta carotene, with the effects of study, sex, and age group being adjusted by stratification. Results: Risk decreased as fiber intake increased; relative risks were 0.79, 0.69, 0.63, and 0.53 for the four highest quintiles of intake compared with the lowest quintile (trend, P