Auditory gamma oscillations predict global symptomatic outcome in the early stages of psychosis: A longitudinal investigation
Auditory gamma oscillations predict global symptomatic outcome in the early stages of psychosis: A longitudinal investigation
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DOI：
10.1016/j.clinph.2018.08.007
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发表时间：
2018-11-01
影响因子：
4.7
通讯作者：
Kasai, Kiyoto
中科院分区：
文献类型：
--
作者：
Koshiyama, Daisuke;Kirihara, Kenji;Kasai, Kiyoto
目的：伽马频段听觉稳态反应(ASSR)被认为反映了小白蛋白阳性的γ-氨基丁酸(GABA)能中间神经元的功能，可能是早期精神病的候选生物标志物。尽管先前的横断面研究表明，早期精神病患者的伽马频段ASSR降低，但伽玛频段ASSR降低是否可以预测长期预后尚不清楚。方法：在这项纵向研究中，我们调查了伽玛频段ASSR降低与早期精神病患者未来整体症状或功能结局的关系。我们测量了34例新发精神分裂症(ROSZ)患者、28名超高危(UHR)患者和30名健康对照(HCS)基线时的40-HzASSR。结果：ROSZ组和UHR组的40-HzASSR均显著降低。在ROSZ组中，衰减的40-HzASSR与未来的整体症状结局相关，但在UHR组中则不相关。结论：在精神病发作后，伽玛频段ASSR的降低可能预测早期精神病的症状结局。意义：伽玛频段ASSR可能是新发精神分裂症患者长期预后的一个潜在有用的生物标志物。(C)2018国际临床神经生理学联合会。爱思唯尔出版，版权所有。
Objectives: The gamma-band auditory steady-state response (ASSR) is thought to reflect the function of parvalbumin-positive gamma-aminobutyric acid (GABA)-ergic interneurons and may be a candidate biomarker in early psychosis. Although previous cross-sectional studies have shown that gamma-band ASSR is reduced in early psychosis, whether reduced gamma-band ASSR could be a predictor of the long-term prognosis remains unknown.Methods: In this longitudinal study, we investigated the association between gamma-band ASSR reduction and future global symptomatic or functional outcome in early psychosis. We measured 40-Hz ASSR in 34 patients with recent-onset schizophrenia (ROSZ), 28 ultra-high risk (UHR) individuals, and 30 healthy controls (HCs) at baseline. After 1-2 years, we evaluated the global assessment of functioning (GAF) in the ROSZ (N = 20) and UHR (N = 20) groups.Results: The 40-Hz ASSR was significantly reduced in the ROSZ and UHR groups. The attenuated 40-Hz ASSR was correlated with the future global symptomatic outcome in the ROSZ, but not in the UHR groups.Conclusions: A reduction in the gamma-band ASSR after the onset of psychosis may predict symptomatic outcomes in early psychosis.Significance: Gamma-band ASSR may be a potentially useful biomarker of the long-term prognosis in patients with recent-onset schizophrenia. (C) 2018 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.