Attenuation Correction Synthesis for Hybrid PET-MR Scanners: Application to Brain Studies
Attenuation Correction Synthesis for Hybrid PET-MR Scanners: Application to Brain Studies
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DOI：
10.1109/tmi.2014.2340135
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发表时间：
2014-12-01
影响因子：
10.6
通讯作者：
Ourselin, Sebastien
中科院分区：
文献类型：
--
作者：
Burgos, Ninon;Cardoso, M. Jorge;Ourselin, Sebastien
衰减校正是正电子发射断层扫描（PET）数据量化的基本要求。在PET/CT采集系统中，从计算机断层摄影（CT）图像导出衰减图。然而，在混合PET/MR扫描仪中，磁共振成像（MRI）图像不直接提供患者特异性衰减图。所提出的工作的目的是通过生成合成CT和衰减图来改善PET/MR扫描仪的衰减校正。通过多图谱信息传播方案生成合成图像，使用局部图像相似性度量将MRI导出的患者形态局部匹配到MRI/CT对的数据库。结果显示，与使用超短回波时间MRI序列的分割方法和简化的基于图谱的方法相比，CT合成和PET重建准确性有显着改善。
Attenuation correction is an essential requirement for quantification of positron emission tomography (PET) data. In PET/CT acquisition systems, attenuation maps are derived from computed tomography (CT) images. However, in hybrid PET/MR scanners, magnetic resonance imaging (MRI) images do not directly provide a patient-specific attenuation map. The aim of the proposed work is to improve attenuation correction for PET/MR scanners by generating synthetic CTs and attenuation maps. The synthetic images are generated through a multi-atlas information propagation scheme, locally matching the MRI-derived patient's morphology to a database of MRI/CT pairs, using a local image similarity measure. Results show significant improvements in CT synthesis and PET reconstruction accuracy when compared to a segmentation method using an ultrashort-echo-time MRI sequence and to a simplified atlas-based method.