A Non-Canonical Cortico-Amygdala Inhibitory Loop
A Non-Canonical Cortico-Amygdala Inhibitory Loop
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DOI：
10.1523/jneurosci.1515-19.2019
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发表时间：
2019-10-23
影响因子：
5.3
通讯作者：
Apicella, Alfonso Junior
中科院分区：
文献类型：
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作者：
Bertero, Alice;Feyen, Paul Luc Caroline;Apicella, Alfonso Junior
区分不同情感价值的听觉信号对于个体的生存和社会互动的成功至关重要。解剖学、电生理学、成像学和光遗传学方法已经确定，听觉皮层（AC）通过远距离兴奋性神经元投射向外侧杏仁核（LA）提供听觉信息，对声音驱动的厌恶/恐惧行为产生影响。在这里，我们测试的假设，LA也收到来自皮层的GABA能投射。我们通过利用光遗传学、解剖学和电生理学方法并直接检查皮质GABA能输入对小鼠（雄性/雌性）AC的LA神经元的功能影响来解决这个基本问题。我们发现，皮层，通过皮质-外侧-杏仁核生长抑素神经元（CLA-SOM），对LA主神经元的输出有直接的抑制作用。我们的研究结果定义了一个CLA长程抑制回路（CLA-SOM抑制投射-> LA主神经元），它控制LA和LA-AC投射神经元的尖峰时间/产生，并将特定功能归因于CLA通信中遗传定义类型的皮层长程GABA能神经元。
Discriminating between auditory signals of different affective value is critical for the survival and success of social interaction of an individual. Anatomical, electrophysiological, imaging, and optogenetics approaches have established that the auditory cortex (AC) by providing auditory information to the lateral amygdala (LA) via long-range excitatory glutamatergic projections has an impact on sound-driven aversive/fear behavior. Here we test the hypothesis that the LA also receives GABAergic projections from the cortex. We addressed this fundamental question by taking advantage of optogenetics, anatomical, and electrophysiology approaches and directly examining the functional effects of cortical GABAergic inputs to LA neurons of the mouse (male/female) AC. We found that the cortex, via cortico-lateral-amygdala somatostatin neurons (CLA-SOM), has a direct inhibitory influence on the output of the LA principal neurons. Our results define a CLA long-range inhibitory circuit (CLA-SOM inhibitory projections -> LA principal neurons) underlying the control of spike timing/generation in LA and LA-AC projecting neurons, and attributes a specific function to a genetically defined type of cortical long-range GABAergic neurons in CLA communication.