NASR: an effective approach for simultaneous noise and artifact suppression in NMR spectroscopy.
NASR: an effective approach for simultaneous noise and artifact suppression in NMR spectroscopy.
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DOI：
10.1021/ac303726p
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发表时间：
2013-02
影响因子：
7.4
通讯作者：
Bin Jiang;Fan Luo;Yiming Ding;Peng Sun;Xu Zhang;Ling Jiang;Conggang Li;X. Mao;Daiwen Yang-
中科院分区：
文献类型：
--
作者：
Bin Jiang;Fan Luo;Yiming Ding;Peng Sun;Xu Zhang;Ling Jiang;Conggang Li;X. Mao;Daiwen Yang-
核磁共振（NMR）光谱作为生物分析，特别是蛋白质结构和动力学研究的有力工具，其固有的低信噪比（SNR）和多维（nD）实验所需的长采集时间的缺点。非均匀采样（NUS）可以有效地加快实验，但往往会在频谱中引入伪影。除了开发高灵敏度的硬件和核磁共振脉冲序列外，数据后处理是一种相对简单和成本有效的方法，可以提高信噪比并抑制伪影。在这项工作中，我们提出了一种有效的方法，同时抑制噪声和文物的基础上reservation原则。该方法简称为NASR，并使用一维，二维和三维（1D，2D和3D）NMR光谱进行测试，这些光谱是使用醚常规或NUS（螺旋和随机，用于3D）方法获得的。结果表明，NASR是快速和适用于改善质量的1D到nD NMR谱与各种采样方案。
As a powerful tool for biological analysis, especially protein structure and dynamic studies, nuclear magnetic resonance (NMR) spectroscopy suffers from intrinsic low signal to nose ratio (SNR) and long acquisition time required for multidimensional (nD) experiments. Nonuniform sampling (NUS) can effectively speed up the experiment but often introduces artifacts into the spectrum. In addition to the development of highly sensitive hardware and NMR pulse sequences, data postprocessing is a relative simple and cost-effective method to improve the SNR and suppress the artifacts. In this work, we propose an effective approach for simultaneously suppressing noise and artifacts based on the resampling principle. The method is named NASR for short and tested using one-, two-, and three-dimensional (1D, 2D, and 3D) NMR spectra that were acquired using ether conventional or NUS (spiral and random, for 3D) approaches. The results reveal that the NASR is fast and applicable for improving the quality of 1D to nD NMR spectra with all kinds of sampling schemes.