Regional grey and white matter volumetric changes in myalgic encephalomyelitis (chronic fatigue syndrome): a voxel-based morphometry 3 T MRI study
Regional grey and white matter volumetric changes in myalgic encephalomyelitis (chronic fatigue syndrome): a voxel-based morphometry 3 T MRI study
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DOI：
10.1259/bjr/93889091
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发表时间：
2012-07-01
影响因子：
2.6
通讯作者：
Gishen, P.
中科院分区：
文献类型：
--
作者：
Puri, B. K.;Jakeman, P. M.;Gishen, P.
目的：肌痛性脑脊髓炎/慢性疲劳综合征（CFS）是否与脑结构改变有关尚不明确。本研究的目的是调查这进行最大的基于体素的形态学研究迄今在CFS.Methods：高分辨率结构3 T脑MRI扫描进行了26例CFS和26名年龄和性别匹配的健康志愿者。使用基于置换的非参数检验，将逐体素广义线性建模应用于处理的MR数据，在t>2.3时形成聚类，并在p <0.05时检验聚类的显著性。
Objective: It is not established whether myalgic encephalomyelitis/chronic fatigue syndrome (CFS) is associated with structural brain changes. The aim of this study was to investigate this by conducting the largest voxel-based morphometry study to date in CFS.Methods: High-resolution structural 3 T cerebral MRI scanning was carried out in 26 patients with CFS and 26 age-and gender-matched healthy volunteers. Voxel-wise generalised linear modelling was applied to the processed MR data using permutation-based non-parametric testing, forming clusters at t>2.3 and testing clusters for significance at p