Association of plant-based diet index with prostate cancer risk
Association of plant-based diet index with prostate cancer risk
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DOI：
10.1093/ajcn/nqab365
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发表时间：
2021-12-15
影响因子：
7.1
通讯作者：
Mucci, Lorelei A.
中科院分区：
文献类型：
--
作者：
Loeb, Stacy;Fu, Benjamin C.;Mucci, Lorelei A.
背景：植物性饮食与多种健康益处和有利的环境影响有关。对于前列腺癌，以前的研究表明特定植物性食物的有益作用（例如，西红柿）和特定动物性食品的潜在有害作用（例如，肉、奶制品）。然而，鲜为人知的是植物为基础的饮食patterns.Objectives：我们试图研究植物为基础的饮食指数和前列腺癌风险之间的关系，包括临床相关diseases.Methods：这是一项前瞻性队列研究，包括47,239名男性在卫生专业人员随访研究（1986-2014）。根据FFQ计算总体和健康的植物性饮食指数。使用考克斯比例风险模型估计HR和95%CI，以检查前列腺癌的发病风险（总人数和按临床类别分列的人数），年龄≥ 65岁的男性。在47239名男性中，6655名男性在随访期间被诊断患有前列腺癌，其中515名在诊断时患有晚期疾病，956名患有致命疾病（转移或死亡）和806例前列腺癌死亡。总体植物性消费量增加与致命性前列腺癌风险显著降低相关（HR：0.81; 95% CI：0.64，1.01; P趋势= 0.04）。在老年男性中，
Background: Plant-based diets are associated with multiple health benefits and a favorable environmental impact. For prostate cancer, previous studies suggest a beneficial role of specific plant-based foods (e.g., tomatoes) and a potentially harmful role of specific animal-based foods (e.g., meat, dairy). However, less is known about plant-based dietary patterns.Objectives: We sought to examine the relation between plant-based diet indices and prostate cancer risk, including clinically relevant disease.Methods: This was a prospective cohort study including 47,239 men in the Health Professionals Follow-Up Study (1986-2014). Overall and healthful plant-based diet indices were calculated from FFQs. Cox proportional hazards models were used to estimate HRs and 95% CIs to examine the risk of incident prostate cancer (total and by clinical category), among men ages = 65 y.Results: Of the 47.239 men, 6655 men were diagnosed with prostate cancer over follow-up, including 515 with advanced-stage disease at diagnosis, 956 with lethal disease (metastasis or death), and 806 prostate cancer deaths. Greater overall plant-based consumption was associated with a significantly lower risk of fatal prostate cancer (HR: 0.81; 95% CI: 0.64, 1.01; P-trend = 0.04). In men aged