Anatomical Evidence for Classical and Extra-classical Receptive Field Completion Across the Discontinuous Horizontal Meridian Representation of Primate Area V2
Anatomical Evidence for Classical and Extra-classical Receptive Field Completion Across the Discontinuous Horizontal Meridian Representation of Primate Area V2
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DOI：
10.1093/cercor/bhn142
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发表时间：
2009-04-01
期刊：
影响因子：
3.7
通讯作者：
Angelucci, Alessandra
中科院分区：
文献类型：
--
作者：
Jeffs, Janelle;Ichida, Jennifer M.;Angelucci, Alessandra
在灵长类动物中，水平子午线（HM）在V2吻侧边界的分裂将该区域分为背侧（V2 d）和腹侧（V2 v）两半（分别代表下视觉象限和上视觉象限），导致HM上的视网膜定位相邻位点在V2内远离。如何在这种不连续的HM表示中保持感知的连续性？在绒猴V2 d注射神经解剖示踪剂表明，V2 d吻侧边界附近的细胞可以保持retinotopic连续性内的经典和超经典的感受野（RF），通过使本地和远程的内和interareal连接与腹侧皮质代表上视觉象限。V2 d神经元位于距V2 d吻侧缘< 0.9-1.3 mm处，其RF可能不穿过HM，与颗粒上下层的V2 v神经元形成非视网膜定位水平连接。V2 d神经元位于距离边界< 0.6-0.9 mm处，其RF可能穿过HM，此外与第4层中的V2 v神经元形成视网膜定位局部连接。V2 d神经元还与纹外皮质的上视野区域进行视区间连接，但不与中央凹代表外的MT或MTc连接。腹侧皮层中的标记连接似乎代表了HM中V2 d中连接场的“缺失”部分。我们的结论是，背侧和腹侧皮质之间的连接可以创建一个二阶不连续的视觉地形内的视野连续性。
In primates, a split of the horizontal meridian (HM) representation at the V2 rostral border divides this area into dorsal (V2d) and ventral (V2v) halves (representing lower and upper visual quadrants, respectively), causing retinotopically neighboring loci across the HM to be distant within V2. How is perceptual continuity maintained across this discontinuous HM representation? Injections of neuroanatomical tracers in marmoset V2d demonstrated that cells near the V2d rostral border can maintain retinotopic continuity within their classical and extra-classical receptive field (RF), by making both local and long-range intra- and interareal connections with ventral cortex representing the upper visual quadrant. V2d neurons located < 0.9-1.3 mm from the V2d rostral border, whose RFs presumably do not cross the HM, make nonretinotopic horizontal connections with V2v neurons in the supra- and infragranular layers. V2d neurons located < 0.6-0.9 mm from the border, whose RFs presumably cross the HM, in addition make retinotopic local connections with V2v neurons in layer 4. V2d neurons also make interareal connections with upper visual field regions of extrastriate cortex, but not of MT or MTc outside the foveal representation. Labeled connections in ventral cortex appear to represent the "missing" portion of the connectional fields in V2d across the HM. We conclude that connections between dorsal and ventral cortex can create visual field continuity within a second-order discontinuous visual topography.