Tradeoff between robustness and elaboration in carotenoid networks produces cycles of avian color diversification.
Tradeoff between robustness and elaboration in carotenoid networks produces cycles of avian color diversification.
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DOI：
10.1186/s13062-015-0073-6
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发表时间：
2015-08-20
期刊：
影响因子：
5.5
通讯作者：
Sanderson MJ
中科院分区：
文献类型：
--
作者：
Badyaev AV;Morrison ES;Belloni V;Sanderson MJ
微观进化和宏观进化之间的联系的解决方案需要在相同的确定性景观（如基因组，代谢或健身网络）上比较这两个过程。我们将这种观点应用于类胡萝卜素色素的进化，产生壮观的鸟类颜色的多样性，并显示基本的类胡萝卜素代谢网络的结构特性反映在全球模式的阐述和多样化的颜色显示。鸟类通过消耗和代谢环境中的几种膳食类胡萝卜素来给自己上色。这种对最上游的外部化合物的基本依赖性本质上限制了颜色加工所需的多步代谢途径的持续进化延伸，除非代谢网络获得鲁棒性-从额外的饮食起点合成相同类胡萝卜素的能力。我们发现，增益和损失的代谢鲁棒性与进化周期的阐述和停滞在鸟类中表达的类胡萝卜素。缺乏代谢的鲁棒性约束谱系的代谢探索的直接生化附近的生态不同的饮食类胡萝卜素，而收益的鲁棒性反复导致持续延长的代谢途径的进化时间尺度和相应的颜色阐述。代谢途径的长度和鲁棒性之间的结构联系可以解释周期性的收敛，在表达类胡萝卜素色素的遗传学上遥远的和生态学上不同的物种;占停滞在类胡萝卜素的颜色在一些生态谱系;并显示如何底层的代谢网络的连接提供了一个微观进化的阐述和宏观进化的多样化之间的机械联系。本文由Junhyong Kim、尤金库宁和Fyodor Kondrashov审阅。有关完整的报告，请参阅审阅者报告部分。本文的在线版本（doi：10.1186/s13062-015-0073-6）包含补充材料，可供授权用户使用。
Resolution of the link between micro- and macroevolution calls for comparing both processes on the same deterministic landscape, such as genomic, metabolic or fitness networks. We apply this perspective to the evolution of carotenoid pigmentation that produces spectacular diversity in avian colors and show that basic structural properties of the underlying carotenoid metabolic network are reflected in global patterns of elaboration and diversification in color displays. Birds color themselves by consuming and metabolizing several dietary carotenoids from the environment. Such fundamental dependency on the most upstream external compounds should intrinsically constrain sustained evolutionary elongation of multi-step metabolic pathways needed for color elaboration unless the metabolic network gains robustness – the ability to synthesize the same carotenoid from an additional dietary starting point. We found that gains and losses of metabolic robustness were associated with evolutionary cycles of elaboration and stasis in expressed carotenoids in birds. Lack of metabolic robustness constrained lineage’s metabolic explorations to the immediate biochemical vicinity of their ecologically distinct dietary carotenoids, whereas gains of robustness repeatedly resulted in sustained elongation of metabolic pathways on evolutionary time scales and corresponding color elaboration. The structural link between length and robustness in metabolic pathways may explain periodic convergence of phylogenetically distant and ecologically distinct species in expressed carotenoid pigmentation; account for stasis in carotenoid colors in some ecological lineages; and show how the connectivity of the underlying metabolic network provides a mechanistic link between microevolutionary elaboration and macroevolutionary diversification. This article was reviewed by Junhyong Kim, Eugene Koonin, and Fyodor Kondrashov. For complete reports, see the Reviewers’ reports section. The online version of this article (doi:10.1186/s13062-015-0073-6) contains supplementary material, which is available to authorized users.